SLC11A2 and VPS35

Number of citations of the paper that reports this interaction (PubMedID 24344282)
43

Data Source:
BioGRID (pull down)

		SLC11A2	VPS35
Description		solute carrier family 11 member 2	VPS35 retromer complex component
Image
GO Annotations	Cellular Component	Cell Nucleus Cytoplasm Mitochondrion Mitochondrial Outer Membrane Lysosomal Membrane Early Endosome Vacuole Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Membrane Apical Plasma Membrane Cytoplasmic Vesicle Brush Border Membrane Late Endosome Membrane Apical Part Of Cell Basal Part Of Cell Perinuclear Region Of Cytoplasm Recycling Endosome Paraferritin Complex Extracellular Vesicle	Mitochondrion Lysosome Lysosomal Membrane Endosome Early Endosome Late Endosome Cytosol Endosome Membrane Postsynaptic Density Retromer Complex Retromer, Cargo-selective Complex Neuron Projection Neuronal Cell Body Perinuclear Region Of Cytoplasm Extracellular Exosome Tubular Endosome Presynapse Glutamatergic Synapse Mitochondrion-derived Vesicle
	Molecular Function	Copper Ion Transmembrane Transporter Activity Iron Ion Transmembrane Transporter Activity Manganese Ion Transmembrane Transporter Activity Protein Binding Cadmium Ion Transmembrane Transporter Activity Cobalt Ion Transmembrane Transporter Activity Ferrous Iron Transmembrane Transporter Activity Lead Ion Transmembrane Transporter Activity Nickel Cation Transmembrane Transporter Activity Solute:proton Symporter Activity Cadmium Ion Binding Transition Metal Ion Transmembrane Transporter Activity	Protein Binding D1 Dopamine Receptor Binding
	Biological Process	Response To Hypoxia Heme Biosynthetic Process Cobalt Ion Transport Copper Ion Transport Iron Ion Transport Manganese Ion Transport Cellular Iron Ion Homeostasis Learning Or Memory Response To Iron Ion Lead Ion Transport Iron Assimilation Iron Ion Transmembrane Transport Copper Ion Transmembrane Transport Nickel Cation Transmembrane Transport Dendrite Morphogenesis Erythrocyte Development Multicellular Organismal Iron Ion Homeostasis Cadmium Ion Transmembrane Transport Manganese Ion Transmembrane Transport Proton Transmembrane Transport	Intracellular Protein Transport Lysosome Organization Synapse Assembly Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Regulation Of Mitochondrion Organization Viral Process Wnt Signaling Pathway Regulation Of Macroautophagy Regulation Of Protein Stability Protein Destabilization Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Homooligomerization Protein Localization To Endosome Retrograde Transport, Endosome To Golgi Mitochondrial Fragmentation Involved In Apoptotic Process Transcytosis Negative Regulation Of Inflammatory Response Voluntary Musculoskeletal Movement Positive Regulation Of Dopamine Receptor Signaling Pathway Negative Regulation Of Cell Death Positive Regulation Of Wnt Protein Secretion Positive Regulation Of Mitochondrial Fission Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Locomotion Involved In Locomotory Behavior Neurotransmitter Receptor Transport, Endosome To Postsynaptic Membrane Vesicle-mediated Transport In Synapse Mitochondrion To Lysosome Transport Neurotransmitter Receptor Transport, Endosome To Plasma Membrane Negative Regulation Of Neuron Death Negative Regulation Of Late Endosome To Lysosome Transport Regulation Of Dendritic Spine Maintenance Positive Regulation Of Dopamine Biosynthetic Process Positive Regulation Of Cellular Protein Catabolic Process Negative Regulation Of Cellular Protein Localization Negative Regulation Of Lysosomal Protein Catabolic Process Regulation Of Presynapse Assembly Retrograde Transport, Endosome To Plasma Membrane Regulation Of Terminal Button Organization
Pathways		Metal ion SLC transporters Defective SLC11A2 causes hypochromic microcytic anemia, with iron overload 1 (AHMIO1) Iron uptake and transport	WNT ligand biogenesis and trafficking
Drugs
Diseases
GWAS
Interacting Genes		2 interacting genes: PRIM1 VPS35	9 interacting genes: APP MTNR1B SLC11A2 SNX1 SNX3 VEGFA VPS26B VPS29 ZNF512B
Entrez ID		4891	55737
HPRD ID		02750	06085
Ensembl ID		ENSG00000110911	ENSG00000069329
Uniprot IDs		A0A0X8GKR4 P49281	Q96QK1
PDB IDs		5F0L 5F0M 5F0P	2R17 5F0J 5F0K 5F0L 5F0M 5F0P 5OSH 5OSI
Enriched GO Terms of Interacting Partners?
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