NPPC and NPR1

Number of citations of the paper that reports this interaction (PubMedID 1660465)
22

Data Source:
BioGRID (pull down)

		NPPC	NPR1
Description		natriuretic peptide C	natriuretic peptide receptor 1
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Secretory Granule Protein-containing Complex	Plasma Membrane Integral Component Of Membrane Receptor Complex
	Molecular Function	Signaling Receptor Binding Hormone Activity Hormone Receptor Binding	Peptide Receptor Activity Guanylate Cyclase Activity Protein Kinase Activity ATP Binding GTP Binding G Protein-coupled Peptide Receptor Activity Natriuretic Peptide Receptor Activity Peptide Hormone Binding Protein Kinase Binding Hormone Binding
	Biological Process	Ossification Response To Hypoxia Growth Plate Cartilage Chondrocyte Differentiation Growth Plate Cartilage Chondrocyte Proliferation CGMP Biosynthetic Process Protein Folding Receptor Guanylyl Cyclase Signaling Pathway Negative Regulation Of Cell Proliferation Post-embryonic Development Positive Regulation Of CGMP-mediated Signaling CGMP-mediated Signaling Reproductive Process Negative Regulation Of Collagen Biosynthetic Process Regulation Of Multicellular Organism Growth Response To Ethanol Positive Regulation Of Osteoblast Differentiation Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Meiotic Cell Cycle Positive Regulation Of Blood Vessel Diameter Negative Regulation Of Oocyte Maturation Regulation Of Cardiac Conduction Negative Regulation Of DNA Biosynthetic Process	CGMP Biosynthetic Process Protein Phosphorylation Signal Transduction Cell Surface Receptor Signaling Pathway Receptor Guanylyl Cyclase Signaling Pathway G Protein-coupled Receptor Signaling Pathway Body Fluid Secretion Regulation Of Blood Pressure Positive Regulation Of CGMP-mediated Signaling Negative Regulation Of Angiogenesis CGMP-mediated Signaling Negative Regulation Of Cell Growth Positive Regulation Of Urine Volume Positive Regulation Of Renal Sodium Excretion Dopamine Metabolic Process Regulation Of Vascular Permeability Negative Regulation Of Smooth Muscle Cell Proliferation Regulation Of Blood Vessel Diameter Regulation Of Cardiac Conduction
Pathways		Physiological factors	Physiological factors
Drugs			Nitroprusside Nitroglycerin Isosorbide Dinitrate Amyl Nitrite Erythrityl Tetranitrate Nesiritide Ularitide
Diseases
GWAS		Height ( 20881960 25282103 25429064 19570815 18391951) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for body mass index ( 28448500)	Mean arterial pressure ( 27618448) Systolic blood pressure ( 27618448)
Interacting Genes		4 interacting genes: MME NPR1 NPR2 NPR3	7 interacting genes: ATF7IP MTDH NPPA NPPB NPPC PRKG1 UBE2D2
Entrez ID		4880	4881
HPRD ID		08975	00165
Ensembl ID		ENSG00000163273	ENSG00000169418
Uniprot IDs		E5LCN7 P23582	A0A140VJE6 P16066
PDB IDs		1JDP
Enriched GO Terms of Interacting Partners?
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