NPHP1 and ARHGAP32

Number of citations of the paper that reports this interaction (PubMedID 18477472)
5

Data Source:
BioGRID (two hybrid)

		NPHP1	ARHGAP32
Description		nephrocystin 1	Rho GTPase activating protein 32
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GO Annotations	Cellular Component	Cytosol Cytoskeleton Cell-cell Junction Adherens Junction Bicellular Tight Junction Membrane Motile Cilium Photoreceptor Connecting Cilium	Golgi Membrane Fibrillar Center Nucleoplasm Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Cell Cortex Endosome Membrane Postsynaptic Density Actin Cytoskeleton Cell Junction Dendritic Spine
	Molecular Function	Structural Molecule Activity Protein Binding	GTPase Activator Activity Protein Binding Phosphatidylinositol Phosphate Binding
	Biological Process	Signal Transduction Excretion Visual Behavior Cell Projection Organization Actin Cytoskeleton Organization Spermatid Differentiation Retina Development In Camera-type Eye Ciliary Basal Body-plasma Membrane Docking Cell-cell Adhesion Positive Regulation Of Bicellular Tight Junction Assembly	Small GTPase Mediated Signal Transduction Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction
Pathways		Anchoring of the basal body to the plasma membrane	Rho GTPase cycle
Drugs
Diseases		Joubert syndrome Nephronophthisis-medullary cystic kidney disease, including; Nephronophthisis (NPH) ; Nephronophthisis-like nephropathy 1; Medullary cystic kidney disease 1; Medullary cystic kidney disease 2 (MSKD2) Senior-Loken syndrome
GWAS			Intracranial aneurysm ( 30823506) Iris color (L* coordinate) ( 29109912) Macular thickness ( 30535121) Metabolite levels (5-HIAA) ( 23319000)
Interacting Genes		16 interacting genes: ADAM15 ARHGAP32 BCAR1 FBXO7 FLNA FLNB FLNC INVS KHDRBS1 NPHP3 NPHP4 PAK2 PTK2B TNK2 TUBB UBQLN4	33 interacting genes: ABI2 ATXN1 BCAR1 CAMK2N2 CDC42 CDH1 CDH2 CRK CRKL CTNNB1 DLG4 DZIP3 FYN GAB1 GAB2 GRAP GRB2 GRIN2A GRIN2B LZTS2 MDFI MEGF10 NCK1 NCK2 NPHP1 NTRK1 PIK3R1 PLCG1 RAC1 RHOA SHC3 SRC TLE5
Entrez ID		4867	9743
HPRD ID		09524	12257
Ensembl ID		ENSG00000144061	ENSG00000134909
Uniprot IDs		B4DQY0 C9JNM7 O15259	A7KAX9 Q86T64
PDB IDs		1S1N 6O1Q	3IUG
Enriched GO Terms of Interacting Partners?
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