NPHP1 and NPHP4

Number of citations of the paper that reports this interaction (PubMedID 26638075)
122

Data Source:
BioGRID (proximity labelling technology, affinity chromatography technology)
HPRD (in vivo, in vitro)

		NPHP1	NPHP4
Description		nephrocystin 1	nephrocystin 4
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Cytoskeleton Cell-cell Junction Adherens Junction Bicellular Tight Junction Membrane Motile Cilium Photoreceptor Connecting Cilium	Nucleoplasm Centrosome Cytosol Cell-cell Junction Bicellular Tight Junction Nuclear Body Ciliary Transition Zone Ciliary Basal Body Intracellular Membrane-bounded Organelle Ribbon Synapse Ciliary Base Non-motile Cilium
	Molecular Function	Structural Molecule Activity Protein Binding	Structural Molecule Activity Protein Binding
	Biological Process	Signal Transduction Excretion Visual Behavior Cell Projection Organization Actin Cytoskeleton Organization Spermatid Differentiation Retina Development In Camera-type Eye Ciliary Basal Body-plasma Membrane Docking Cell-cell Adhesion Positive Regulation Of Bicellular Tight Junction Assembly	Signal Transduction Visual Behavior Actin Cytoskeleton Organization Flagellated Sperm Motility Hippo Signaling Photoreceptor Cell Outer Segment Organization Photoreceptor Cell Maintenance Retina Development In Camera-type Eye Negative Regulation Of Canonical Wnt Signaling Pathway Ciliary Basal Body-plasma Membrane Docking Cell-cell Adhesion Positive Regulation Of Bicellular Tight Junction Assembly Protein Localization To Ciliary Transition Zone
Pathways		Anchoring of the basal body to the plasma membrane	Signaling by Hippo Anchoring of the basal body to the plasma membrane
Drugs
Diseases		Joubert syndrome Nephronophthisis-medullary cystic kidney disease, including; Nephronophthisis (NPH) ; Nephronophthisis-like nephropathy 1; Medullary cystic kidney disease 1; Medullary cystic kidney disease 2 (MSKD2) Senior-Loken syndrome	Senior-Loken syndrome Nephronophthisis-medullary cystic kidney disease, including; Nephronophthisis (NPH) ; Nephronophthisis-like nephropathy 1; Medullary cystic kidney disease 1; Medullary cystic kidney disease 2 (MSKD2)
GWAS			Dimensional psychopathology (Positive) ( 29496196) QT interval ( 19305408) Response to taxane treatment (placlitaxel) ( 23006423)
Interacting Genes		16 interacting genes: ADAM15 ARHGAP32 BCAR1 FBXO7 FLNA FLNB FLNC INVS KHDRBS1 NPHP3 NPHP4 PAK2 PTK2B TNK2 TUBB UBQLN4	2 interacting genes: NPHP1 RPGRIP1
Entrez ID		4867	261734
HPRD ID		09524	06238
Ensembl ID		ENSG00000144061	ENSG00000131697
Uniprot IDs		B4DQY0 C9JNM7 O15259	B3KW36 O75161
PDB IDs		1S1N 6O1Q
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?