NOS1 and DLG2

Number of citations of the paper that reports this interaction (PubMedID 8625413)
368

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid, in vitro)

		NOS1	DLG2
Description		nitric oxide synthase 1	discs large MAGUK scaffold protein 2
Image
GO Annotations	Cellular Component	Photoreceptor Inner Segment Cell Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Cytoskeleton Plasma Membrane Caveola Vesicle Membrane Postsynaptic Density Sarcoplasmic Reticulum Z Disc Cell Junction T-tubule Protein-containing Complex Sarcolemma Dendritic Spine Calyx Of Held Membrane Raft Synapse Perinuclear Region Of Cytoplasm Cell Periphery Ryanodine Receptor Complex	Cytosol Plasma Membrane Voltage-gated Potassium Channel Complex Ionotropic Glutamate Receptor Complex Postsynaptic Density Membrane Basolateral Plasma Membrane Cell Junction Neuromuscular Junction Neuron Projection Perikaryon Juxtaparanode Region Of Axon Postsynaptic Density Membrane Glutamatergic Synapse Axon Cytoplasm
	Molecular Function	NADPH-hemoprotein Reductase Activity Nitric-oxide Synthase Activity Protein Binding Calmodulin Binding FMN Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, NAD(P)H As One Donor, And Incorporation Of One Atom Of Oxygen Sodium Channel Regulator Activity Heme Binding Tetrahydrobiopterin Binding Arginine Binding Ion Channel Binding Cadmium Ion Binding Calcium-dependent Protein Binding Flavin Adenine Dinucleotide Binding NADP Binding Scaffold Protein Binding	Guanylate Kinase Activity Protein Binding Kinase Binding Structural Constituent Of Postsynaptic Density
	Biological Process	Response To Hypoxia Regulation Of Sodium Ion Transport Arginine Catabolic Process Nitric Oxide Biosynthetic Process Muscle Contraction Striated Muscle Contraction Nitric Oxide Mediated Signal Transduction Myoblast Fusion Response To Heat Response To Hormone Negative Regulation Of Calcium Ion Transport Into Cytosol Peptidyl-cysteine S-nitrosylation Positive Regulation Of Guanylate Cyclase Activity Response To Lipopolysaccharide Positive Regulation Of Peptidyl-serine Phosphorylation Multicellular Organismal Response To Stress Positive Regulation Of Histone Acetylation Neurotransmitter Biosynthetic Process Vasodilation Exogenous Drug Catabolic Process Negative Regulation Of Potassium Ion Transport Cell Redox Homeostasis Negative Regulation Of Blood Pressure Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Neurogenesis Negative Regulation Of Hydrolase Activity Negative Regulation Of Serotonin Uptake Negative Regulation Of Calcium Ion Transport Oxidation-reduction Process Regulation Of Cardiac Muscle Contraction Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Cellular Response To Growth Factor Stimulus Positive Regulation Of The Force Of Heart Contraction Retrograde Trans-synaptic Signaling By Nitric Oxide Positive Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Involved In Heart Process Positive Regulation Of Sodium Ion Transmembrane Transport Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel Regulation Of Cardiac Conduction	MAPK Cascade Chemical Synaptic Transmission Embryo Development Negative Regulation Of Phosphatase Activity Sensory Perception Of Pain Cellular Response To Potassium Ion Receptor Clustering Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity GMP Metabolic Process GDP Metabolic Process Receptor Localization To Synapse Cell-cell Adhesion Maintenance Of Postsynaptic Density Structure Anterograde Axonal Protein Transport Retrograde Axonal Protein Transport Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Regulation Of NMDA Receptor Activity
Pathways		ROS and RNS production in phagocytes Nitric oxide stimulates guanylate cyclase Ion homeostasis	Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Ras activation upon Ca2+ influx through NMDA receptor RAF/MAP kinase cascade Neurexins and neuroligins Neurexins and neuroligins Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation
Drugs		L-Citrulline L-N(Omega)-Nitroarginine-2,4-L-Diaminobutyric Amide Formic Acid 3-Bromo-7-Nitroindazole N-{(4s)-4-Amino-5-[(2-Aminoethyl)Amino]Pentyl}-N'-Nitroguanidine N-(3-(Aminomethyl)Benzyl)Acetamidine L-N(Omega)-Nitroarginine-(4r)-Amino-L-Proline Amide N-Isopropyl-N'-Hydroxyguanidine N-Omega-Propyl-L-Arginine N-Butyl-N'-Hydroxyguanidine S-Ethyl-N-[4-(Trifluoromethyl)Phenyl]Isothiourea N-Omega-Hydroxy-L-Arginine Flavin adenine dinucleotide Riboflavin Monophosphate N-(4-(2-((3-Chlorophenylmethyl)Amino)Ethyl)Phenyl)-2-Thiophecarboxamidine 2'-Monophosphoadenosine 5'-Diphosphoribose S-Ethyl-N-Phenyl-Isothiourea N5-(1-Imino-3-Butenyl)-L-Ornithine 5-N-Allyl-Arginine Nitroarginine NXN-188 N-{(3S,4S)-4-[(6-AMINO-4-METHYLPYRIDIN-2-YL)METHYL]PYRROLIDIN-3-YL}-N'-(4-CHLOROBENZYL)ETHANE-1,2-DIAMINE N-{(3R,4S)-4-[(6-amino-4-methylpyridin-2-yl)methyl]pyrrolidin-3-yl}-N'-(3-chlorobenzyl)ethane-1,2-diamine Methylene blue
Diseases
GWAS		Baseline cortisol levels in response to low dose short synacthen test in corticosteroid treated asthma ( 29551627) Colorectal cancer ( 26151821) Colorectal cancer or advanced adenoma ( 30510241) Disability (impaired activities of daily living) ( 31707593) General factor of neuroticism ( 30867560) Neuroticism ( 29255261) Schizophrenia ( 28991256 30285260)	Age at first sexual intercourse ( 27089180) Attention function in attention deficit hyperactive disorder ( 26174813) BMI at adiposity rebound ( 31840077) Body fat mass ( 28552196) Body mass index ( 28552196) Cerebrospinal fluid t-tau:AB1-42 ratio ( 28641921) Chronic obstructive pulmonary disease ( 25584925) Chronic periodontitis ( 25008200) Familial squamous cell lung carcinoma ( 29924316) Height ( 28552196) Influenza A (H1N1) infection ( 26379185) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Migraine without aura ( 28952330) Mild influenza (H1N1) infection ( 26379185) Modic changes ( 30808802) Myopia ( 27182965) Obesity-related traits ( 23251661) Pallidum volume ( 31530798) Parkinson's disease ( 25064009 28892059 28011712 17052657) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Phospholipid levels (plasma) ( 22359512) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Protein quantitative trait loci ( 18464913) Putamen volume ( 29147026) Response to fenofibrate (triglyceride levels) ( 27002377) Response to TNF inhibitor in rheumatoid arthritis (change in swollen 28-joint count) ( 30166627) Schizophrenia ( 30285260) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Subcortical brain region volumes ( 25607358) Trunk fat mass ( 28552196) Type 2 diabetes ( 31049640) Urate levels in overweight individuals ( 25811787) Weight ( 28552196) Wilms tumor ( 22544364)
Interacting Genes		33 interacting genes: ADRA1A ADRA1B ADRA1D ADRB1 ADRB2 ARG1 ATP2B4 BDKRB2 CAMK1 CAMK2A CAMK4 CAV3 CTBP1 DLG2 DLG4 DLGAP2 DYNLL1 HMOX1 HSP90AA1 NOS1AP NOSIP PFKM PRKACA PRKCA PRKD1 PTPN6 PTPRN RASD1 SNTA1 STUB1 SYN1 VAC14 ZDHHC23	40 interacting genes: ABCA1 ATP2B2 ATP2B4 CACNG2 CNKSR2 CRIPT DLG1 DLG4 DLGAP1 ERBB4 FASLG FZD1 FZD4 FZD7 GLS2 GRID1 GRID2 GRIN1 GRIN2A GRIN2B GRIN2D GUCY1A2 KCNA4 KCNJ12 KCNJ2 KCNJ4 KHDRBS1 KIF1B LIN7A LRP2 MAP1A MAPK12 NLGN1 NLGN2 NLGN3 NOS1 SCN4A SCN5A SEMA4C WNT3A
Entrez ID		4842	1740
HPRD ID		01226	04663
Ensembl ID		ENSG00000089250	ENSG00000150672
Uniprot IDs		A0PJJ7 B3VK56 B4DG68 P29475	B7Z2T4 E9PN83 Q15700
PDB IDs		4D1N 4UCH 4UH5 4UH6 4V3U 5ADF 5ADG 5ADI 5FVU 5FVV 5FVW 5FVX 5UO1 5UO2 5UO3 5UO4 5UO5 5UO6 5UO7 5VUV 5VUW 5VUX 5VUY 5VUZ 5VV0 5VV1 5VV2 5VV3 5VV4 5VV5 6AUY 6AUZ 6AV0 6AV1 6AV2 6AV3 6AV4 6AV5 6CIC 6CID 6NG1 6NG2 6NG4 6NG5 6NG6 6NG7 6NG8 6NGA 6NGB 6NGC 6NGD 6NGE 6NGF 6NGH 6NGI 6NHB 6NHC	2BYG 2HE2
Enriched GO Terms of Interacting Partners?
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