NOS1 and ADRA1A

Number of citations of the paper that reports this interaction (PubMedID 12184796)
7

Data Source:
HPRD (in vivo)

		NOS1	ADRA1A
Description		nitric oxide synthase 1	adrenoceptor alpha 1A
Image			No pdb structure
GO Annotations	Cellular Component	Photoreceptor Inner Segment Cell Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Cytoskeleton Plasma Membrane Caveola Vesicle Membrane Postsynaptic Density Sarcoplasmic Reticulum Z Disc Cell Junction T-tubule Protein-containing Complex Sarcolemma Dendritic Spine Calyx Of Held Membrane Raft Synapse Perinuclear Region Of Cytoplasm Cell Periphery Ryanodine Receptor Complex	Cell Nucleus Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Caveola Z Disc T-tubule Nuclear Membrane Dopaminergic Synapse Glutamatergic Synapse GABA-ergic Synapse Integral Component Of Postsynaptic Membrane Integral Component Of Presynaptic Membrane
	Molecular Function	NADPH-hemoprotein Reductase Activity Nitric-oxide Synthase Activity Protein Binding Calmodulin Binding FMN Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, NAD(P)H As One Donor, And Incorporation Of One Atom Of Oxygen Sodium Channel Regulator Activity Heme Binding Tetrahydrobiopterin Binding Arginine Binding Ion Channel Binding Cadmium Ion Binding Calcium-dependent Protein Binding Flavin Adenine Dinucleotide Binding NADP Binding Scaffold Protein Binding	Adrenergic Receptor Activity Alpha1-adrenergic Receptor Activity Protein Binding Protein Heterodimerization Activity
	Biological Process	Response To Hypoxia Regulation Of Sodium Ion Transport Arginine Catabolic Process Nitric Oxide Biosynthetic Process Muscle Contraction Striated Muscle Contraction Nitric Oxide Mediated Signal Transduction Myoblast Fusion Response To Heat Response To Hormone Negative Regulation Of Calcium Ion Transport Into Cytosol Peptidyl-cysteine S-nitrosylation Positive Regulation Of Guanylate Cyclase Activity Response To Lipopolysaccharide Positive Regulation Of Peptidyl-serine Phosphorylation Multicellular Organismal Response To Stress Positive Regulation Of Histone Acetylation Neurotransmitter Biosynthetic Process Vasodilation Exogenous Drug Catabolic Process Negative Regulation Of Potassium Ion Transport Cell Redox Homeostasis Negative Regulation Of Blood Pressure Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Neurogenesis Negative Regulation Of Hydrolase Activity Negative Regulation Of Serotonin Uptake Negative Regulation Of Calcium Ion Transport Oxidation-reduction Process Regulation Of Cardiac Muscle Contraction Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Cellular Response To Growth Factor Stimulus Positive Regulation Of The Force Of Heart Contraction Retrograde Trans-synaptic Signaling By Nitric Oxide Positive Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Involved In Heart Process Positive Regulation Of Sodium Ion Transmembrane Transport Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel Regulation Of Cardiac Conduction	Negative Regulation Of Heart Rate Involved In Baroreceptor Response To Increased Systemic Arterial Blood Pressure Norepinephrine-epinephrine Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure Positive Regulation Of Heart Rate By Epinephrine-norepinephrine Positive Regulation Of The Force Of Heart Contraction By Epinephrine-norepinephrine Positive Regulation Of Systemic Arterial Blood Pressure Apoptotic Process Smooth Muscle Contraction Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Activation Of Phospholipase C Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Cell-cell Signaling Adult Heart Development Aging Behavior Negative Regulation Of Cell Proliferation Response To Hormone Negative Regulation Of Autophagy Positive Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Synaptic Transmission, GABAergic Negative Regulation Of Rho Protein Signal Transduction Intracellular Signal Transduction Response To Drug Positive Regulation Of MAPK Cascade Positive Regulation Of Action Potential Positive Regulation Of Vasoconstriction Positive Regulation Of Smooth Muscle Contraction Micturition Calcium Ion Transport Into Cytosol Positive Regulation Of Cardiac Muscle Contraction Cell Growth Involved In Cardiac Muscle Cell Development Positive Regulation Of ERK1 And ERK2 Cascade Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Positive Regulation Of Protein Kinase C Signaling Pilomotor Reflex Positive Regulation Of Non-membrane Spanning Protein Tyrosine Kinase Activity Regulation Of Synaptic Vesicle Exocytosis
Pathways		ROS and RNS production in phagocytes Nitric oxide stimulates guanylate cyclase Ion homeostasis	Adrenoceptors G alpha (q) signalling events G alpha (12/13) signalling events
Drugs		L-Citrulline L-N(Omega)-Nitroarginine-2,4-L-Diaminobutyric Amide Formic Acid 3-Bromo-7-Nitroindazole N-{(4s)-4-Amino-5-[(2-Aminoethyl)Amino]Pentyl}-N'-Nitroguanidine N-(3-(Aminomethyl)Benzyl)Acetamidine L-N(Omega)-Nitroarginine-(4r)-Amino-L-Proline Amide N-Isopropyl-N'-Hydroxyguanidine N-Omega-Propyl-L-Arginine N-Butyl-N'-Hydroxyguanidine S-Ethyl-N-[4-(Trifluoromethyl)Phenyl]Isothiourea N-Omega-Hydroxy-L-Arginine Flavin adenine dinucleotide Riboflavin Monophosphate N-(4-(2-((3-Chlorophenylmethyl)Amino)Ethyl)Phenyl)-2-Thiophecarboxamidine 2'-Monophosphoadenosine 5'-Diphosphoribose S-Ethyl-N-Phenyl-Isothiourea N5-(1-Imino-3-Butenyl)-L-Ornithine 5-N-Allyl-Arginine Nitroarginine NXN-188 N-{(3S,4S)-4-[(6-AMINO-4-METHYLPYRIDIN-2-YL)METHYL]PYRROLIDIN-3-YL}-N'-(4-CHLOROBENZYL)ETHANE-1,2-DIAMINE N-{(3R,4S)-4-[(6-amino-4-methylpyridin-2-yl)methyl]pyrrolidin-3-yl}-N'-(3-chlorobenzyl)ethane-1,2-diamine Methylene blue	Amphetamine Midodrine Citalopram Ziprasidone Cabergoline Dapiprazole Amitriptyline Olanzapine Alfuzosin Clozapine Norepinephrine Mirtazapine Mirtazapine Phenylephrine Loxapine Promazine Dipivefrin Droperidol Prazosin Imipramine Chlorpromazine Chlorpromazine Nortriptyline Amoxapine Amoxapine Clonidine Doxazosin Labetalol Metaraminol Nicardipine Trazodone Verapamil Epinephrine Thioridazine Phentolamine Ergotamine Nicergoline Tamsulosin Methoxamine Trimipramine Risperidone Epinastine Propiomazine Tolazoline Fenoldopam Trifluoperazine Pseudoephedrine Benzphetamine Flupentixol Quinidine Phenoxybenzamine Maprotiline Oxymetazoline Apraclonidine Ergoloid mesylate Promethazine Carvedilol Doxepin Nefazodone Desipramine Terazosin Escitalopram Pergolide Bromocriptine Quetiapine Aripiprazole Ergonovine Paliperidone Bevantolol Ephedrine Mephentermine Methotrimeprazine 4-Methoxyamphetamine Dextroamphetamine Phendimetrazine Acepromazine Thioproperazine Zuclopenthixol Dronedarone Iloperidone R450 Epicept NP-1 Sertindole Mianserin Silodosin Asenapine Droxidopa Xylometazoline Isometheptene Naphazoline Tetryzoline Perospirone Indoramin Dosulepin Etoperidone Cirazoline Synephrine Niguldipine Tiapride
Diseases
GWAS		Baseline cortisol levels in response to low dose short synacthen test in corticosteroid treated asthma ( 29551627) Colorectal cancer ( 26151821) Colorectal cancer or advanced adenoma ( 30510241) Disability (impaired activities of daily living) ( 31707593) General factor of neuroticism ( 30867560) Neuroticism ( 29255261) Schizophrenia ( 28991256 30285260)	Blood metabolite levels ( 24816252) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Response to amphetamines ( 22952603) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858)
Interacting Genes		33 interacting genes: ADRA1A ADRA1B ADRA1D ADRB1 ADRB2 ARG1 ATP2B4 BDKRB2 CAMK1 CAMK2A CAMK4 CAV3 CTBP1 DLG2 DLG4 DLGAP2 DYNLL1 HMOX1 HSP90AA1 NOS1AP NOSIP PFKM PRKACA PRKCA PRKD1 PTPN6 PTPRN RASD1 SNTA1 STUB1 SYN1 VAC14 ZDHHC23	10 interacting genes: ABR ADRA1B ADRA1D BMP1 CXCR1 CXCR2 FLNC NOS1 PPP1R9B RGS2
Entrez ID		4842	148
HPRD ID		01226	00081
Ensembl ID		ENSG00000089250	ENSG00000120907
Uniprot IDs		A0PJJ7 B3VK56 B4DG68 P29475	B0ZBD3 P35348
PDB IDs		4D1N 4UCH 4UH5 4UH6 4V3U 5ADF 5ADG 5ADI 5FVU 5FVV 5FVW 5FVX 5UO1 5UO2 5UO3 5UO4 5UO5 5UO6 5UO7 5VUV 5VUW 5VUX 5VUY 5VUZ 5VV0 5VV1 5VV2 5VV3 5VV4 5VV5 6AUY 6AUZ 6AV0 6AV1 6AV2 6AV3 6AV4 6AV5 6CIC 6CID 6NG1 6NG2 6NG4 6NG5 6NG6 6NG7 6NG8 6NGA 6NGB 6NGC 6NGD 6NGE 6NGF 6NGH 6NGI 6NHB 6NHC
Enriched GO Terms of Interacting Partners?
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