SNU13 and POLA2

Number of citations of the paper that reports this interaction (PubMedID 16169070)
820

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		SNU13	POLA2
Description		small nuclear ribonucleoprotein 13	DNA polymerase alpha 2, accessory subunit
Image
GO Annotations	Cellular Component	Dense Fibrillar Component Nucleus Nucleoplasm U4atac SnRNP Nucleolus Box C/D SnoRNP Complex Small-subunit Processome Protein-containing Complex U4/U6 X U5 Tri-snRNP Complex U2-type Precatalytic Spliceosome Precatalytic Spliceosome	Nucleoplasm Alpha DNA Polymerase:primase Complex Cytosol
	Molecular Function	RNA Binding Protein Binding SnoRNA Binding U4 SnRNA Binding U4atac SnRNA Binding U3 SnoRNA Binding Box C/D SnoRNA Binding ATPase Binding	Molecular_function DNA Binding DNA-directed DNA Polymerase Activity
	Biological Process	MRNA Splicing, Via Spliceosome Maturation Of LSU-rRNA Box C/D SnoRNP Assembly RRNA Processing Single Fertilization Maturation Of SSU-rRNA	G1/S Transition Of Mitotic Cell Cycle DNA Replication DNA Replication Initiation Telomere Maintenance Via Semi-conservative Replication DNA Biosynthetic Process
Pathways		rRNA modification in the nucleus and cytosol Major pathway of rRNA processing in the nucleolus and cytosol mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway	Inhibition of replication initiation of damaged DNA by RB1/E2F1 Polymerase switching on the C-strand of the telomere Telomere C-strand synthesis initiation DNA replication initiation Activation of the pre-replicative complex Polymerase switching Removal of the Flap Intermediate Processive synthesis on the lagging strand
Drugs		Alpha-Hydroxy-Beta-Phenyl-Propionic Acid Anisomycin	Dacarbazine
Diseases
GWAS			Acne (severe) ( 24927181)
Interacting Genes		14 interacting genes: CDKN2C CHST1 GTF3C1 HSPB2 LRIF1 MAP1LC3B NUFIP1 POLA2 PPIH RAD17 RBM10 RHOU SNW1 XRCC6	41 interacting genes: AGO2 AKTIP APP ARL2 ASCC2 ATL3 ATP5F1C CATSPERZ CPE CRELD1 DCP2 DDX24 DHX34 EIF6 EZH2 FAM219A FGFR3 FRZB HDAC6 HELB HGH1 IGFBP3 KCNE3 KDM2A KLF6 LRPAP1 MFHAS1 NR4A1 PARP1 POLA1 PRIM2 PRPF38A RBM23 SAC3D1 SETDB1 SNU13 STK40 TMEM216 ULK2 XPNPEP1 ZNRD2
Entrez ID		4809	23649
HPRD ID		03197	10160
Ensembl ID		ENSG00000100138	ENSG00000014138
Uniprot IDs		P55769 Q6FHM6	Q14181
PDB IDs		1E7K 2JNB 2OZB 3JCR 3SIU 3SIV 5O9Z 6AH0 6AHD 6QW6 6QX9	2KEB 4E2I 4Y97 5EXR
Enriched GO Terms of Interacting Partners?
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