NFKBIB and MCC

Number of citations of the paper that reports this interaction (PubMedID 14743216)
300

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		NFKBIB	MCC
Description		NFKB inhibitor beta	MCC regulator of WNT signaling pathway
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytosol	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Lamellipodium Cytoplasmic Ribonucleoprotein Granule
	Molecular Function	Transcription Coactivator Activity Protein Binding	Protein Binding Signaling Receptor Activity
	Biological Process	Transcription, DNA-templated Signal Transduction Cellular Response To Lipopolysaccharide Positive Regulation Of Nucleic Acid-templated Transcription	Signal Transduction Negative Regulation Of Epithelial Cell Migration Wnt Signaling Pathway Establishment Of Protein Localization Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Canonical Wnt Signaling Pathway
Pathways		Activation of NF-kappaB in B cells RIP-mediated NFkB activation via ZBP1 TAK1 activates NFkB by phosphorylation and activation of IKKs complex TRAF6 mediated NF-kB activation
Drugs
Diseases
GWAS			Brain cytoarchitecture ( 20308991) Cerebral amyloid angiopathy ( 25188341) Emphysema annual change measurement in smokers (adjusted lung density) ( 31324189) Height ( 31562340) Metabolite levels ( 23823483) Neurofibrillary tangles ( 31497858)
Interacting Genes		41 interacting genes: APP BAK1 BTRC CD3EAP CDC25A CHUK CSNK2A1 CUL1 DNAJA3 ESR2 FHL3 GIT2 IKBKB IKBKG KPNA2 LRPPRC MCC MTIF2 NCOR2 NFKB1 NFKB2 NFKBIA NGFR NKIRAS1 NKIRAS2 PDCD2 POLR1A POLR1B POLR1C POLR1D POLR1E POLR2H POLR2L PPARG RASAL2 REL RELA RXRA SKP1 TSPAN1 VPS52	10 interacting genes: APP CBX5 CSNK1E DYNC1I1 ERBIN GTF2E2 MTNR1A NEK2 NFKBIB STOML2
Entrez ID		4793	4163
HPRD ID		07260	01157
Ensembl ID		ENSG00000104825	ENSG00000171444
Uniprot IDs		G5E9C2 Q15653	P23508
PDB IDs			6MTU
Enriched GO Terms of Interacting Partners?
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