NEFH and STXBP1

Number of citations of the paper that reports this interaction (PubMedID 12963086)
14

Data Source:
HPRD (in vivo)

		NEFH	STXBP1
Description		neurofilament heavy	syntaxin binding protein 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Neurofilament Postsynaptic Density Axon Neurofibrillary Tangle Schaffer Collateral - CA1 Synapse Postsynaptic Intermediate Filament Cytoskeleton	Nucleoplasm Cytoplasm Mitochondrion Cytosol Cytoskeleton Plasma Membrane Axon Platelet Alpha Granule Protein-containing Complex Phagocytic Vesicle Perinuclear Region Of Cytoplasm Presynaptic Active Zone Membrane Extracellular Exosome Postsynapse Glutamatergic Synapse
	Molecular Function	Structural Constituent Of Cytoskeleton Microtubule Binding Kinesin Binding Protein Kinase Binding Protein Binding, Bridging Dynein Complex Binding Structural Constituent Of Postsynaptic Intermediate Filament Cytoskeleton	SNARE Binding RNA Binding Protein Binding Syntaxin-1 Binding Protein Kinase Binding Protein Domain Specific Binding Syntaxin Binding Identical Protein Binding Phospholipase Binding Protein N-terminus Binding
	Biological Process	Microtubule Cytoskeleton Organization Axonogenesis Cell Projection Assembly Neurofilament Bundle Assembly Peripheral Nervous System Neuron Axonogenesis Neurofilament Cytoskeleton Organization Axon Development Postsynaptic Intermediate Filament Cytoskeleton Organization Regulation Of Organelle Transport Along Microtubule Cellular Response To Leukemia Inhibitory Factor	Platelet Degranulation Developmental Process Involved In Reproduction Vesicle Docking Involved In Exocytosis Neurotransmitter Secretion Neuromuscular Synaptic Transmission Axon Target Recognition Regulation Of Synaptic Vesicle Priming Glutamate Secretion Protein Transport Synaptic Vesicle Priming Synaptic Vesicle Maturation Negative Regulation Of Protein Complex Assembly Regulation Of Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Negative Regulation Of Synaptic Transmission, GABAergic Response To Estradiol SNARE Complex Assembly Regulation Of SNARE Complex Assembly Positive Regulation Of Mast Cell Degranulation Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Calcium Ion-dependent Exocytosis Protein Stabilization Long-term Synaptic Depression Platelet Aggregation Cellular Response To Interferon-gamma Protein Localization To Plasma Membrane Presynaptic Dense Core Vesicle Exocytosis Positive Regulation Of Vesicle Docking Positive Regulation Of Glutamate Secretion, Neurotransmission Regulation Of Acrosomal Vesicle Exocytosis
Pathways			Regulation of insulin secretion Neurexins and neuroligins
Drugs
Diseases		Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease	Early infantile epileptic encephalopathy; Ohtahara syndrome
GWAS			Whole brain grey matter density ( 31530798)
Interacting Genes		5 interacting genes: MAPK1 NEFL NEFM PKN1 STXBP1	31 interacting genes: APBA1 APBA2 APP C19orf57 CDK5 CDK5R1 DOC2A DOC2B HGS MAPT MEOX2 MTDH MTNR1A NEFH NEFM PLD1 PLD2 PRKCA PRKCB PRKCG SPTBN1 SQSTM1 STOM STX1A STX1B STX2 STX3 STX5 SYTL4 TRIM38 USO1
Entrez ID		4744	6812
HPRD ID		01204	04235
Ensembl ID		ENSG00000100285	ENSG00000136854
Uniprot IDs		P12036	P61764
PDB IDs
Enriched GO Terms of Interacting Partners?
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