NDUFA4 and FBLN5

		NDUFA4	FBLN5
Description		NDUFA4 mitochondrial complex associated	fibulin 5
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Respiratory Chain Complex I Mitochondrial Respiratory Chain Complex IV	Extracellular Region Extracellular Space Extracellular Matrix Collagen-containing Extracellular Matrix Extracellular Exosome Elastic Fiber
	Molecular Function	Cytochrome-c Oxidase Activity Protein Binding NADH Dehydrogenase (ubiquinone) Activity Protein-containing Complex Binding	Integrin Binding Calcium Ion Binding Protein Binding Protein C-terminus Binding Extracellular Matrix Constituent Conferring Elasticity Protein Homodimerization Activity
	Biological Process	Mitochondrial Electron Transport, NADH To Ubiquinone Mitochondrial Electron Transport, Cytochrome C To Oxygen Proton Transmembrane Transport	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Growth Cell-matrix Adhesion Negative Regulation Of Angiogenesis Extracellular Matrix Organization Positive Regulation Of Osteoblast Proliferation Protein Localization To Cell Surface Positive Regulation Of Transcription By RNA Polymerase II Secretion Elastic Fiber Assembly Intramembranous Bone Growth Regulation Of Removal Of Superoxide Radicals
Pathways		TP53 Regulates Metabolic Genes Respiratory electron transport	Elastic fibre formation Molecules associated with elastic fibres Molecules associated with elastic fibres
Drugs		NADH
Diseases			Macular degeneration, including: Age-related macular degeneration (ARMD); Patterned dystrophy of retinal pigment epithelium (PDREP); Retinal macular dystrophy 2 (MCDR2); X-linked atrophic macular degeneration (MDXLA) Cutis laxa, including: Autosomal dominant cutis laxa (ADCL); Autosomal recessive cutis laxa I (ARCL1); Autosomal recessive cutis laxa II (ARCL2); X-linked recessive cutis laxa (XRCL); Wrinkly skin syndrome
GWAS		Dental caries (decayed, missing and filled teeth) ( 31533690) Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189) Heschl's gyrus morphology ( 25130324) Lung cancer ( 28604730) Mercury levels ( 26025379) Metabolite levels ( 23823483)	Diastolic blood pressure ( 30578418) HDL cholesterol levels x thiazide or thiazide-like diuretics use interaction ( 31806883) Heel bone mineral density ( 30598549) Height ( 25429064 31562340 18391951) Optic disc size ( 31809533) Pulse pressure ( 27841878 30578418) Waist circumference adjusted for body mass index ( 28552196)
Interacting Genes		3 interacting genes: APP FBLN5 PARK7	21 interacting genes: ATN1 GFI1B GSC LGMN LOXL1 LPA MEOX2 NDUFA4 OTX1 PAXIP1 PDIA3 PPP2R5C PRNP PSMC1 SERPINA1 SERPINA5 SOD3 ST3GAL3 TOP3B TRIP13 XCL1
Entrez ID		4697	10516
HPRD ID		04831	05204
Ensembl ID		ENSG00000189043	ENSG00000140092
Uniprot IDs		A0A024R9Z0 O00483	A0A024R6G3 Q9UBX5
PDB IDs		5Z62
Enriched GO Terms of Interacting Partners?
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