NCL and ADAP2

Number of citations of the paper that reports this interaction (PubMedID 18298663)
6

Data Source:
BioGRID (pull down)

		NCL	ADAP2
Description		nucleolin	ArfGAP with dual PH domains 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex Nucleolus Cell Cortex Membrane Cytoplasmic Ribonucleoprotein Granule Extracellular Exosome Ribonucleoprotein Complex	Cytoplasm Mitochondrial Envelope Plasma Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	RNA Binding Protein Binding Protein C-terminus Binding Telomeric DNA Binding Identical Protein Binding DNA Topoisomerase Binding MRNA 5'-UTR Binding	GTPase Activator Activity Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Protein Binding, Bridging Phosphatidylinositol-3,4-bisphosphate Binding Inositol 1,3,4,5 Tetrakisphosphate Binding Metal Ion Binding
	Biological Process	Angiogenesis Negative Regulation Of Translation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of MRNA Splicing, Via Spliceosome Regulation Of RNA Metabolic Process Cellular Response To Epidermal Growth Factor Stimulus Positive Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I Cellular Response To Leukemia Inhibitory Factor	Heart Development Positive Regulation Of GTPase Activity Inositol Lipid-mediated Signaling
Pathways		Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases
GWAS		Attention deficit hyperactivity disorder ( 23728934) Common carotid intima-media thickness in HIV negative individuals ( 29206233) Eating disorders (purging via substances) ( 23568457) Height ( 31562340) Noise-induced hearing loss ( 26121033)	Height ( 28552196) Mean corpuscular hemoglobin ( 27863252) Mean corpuscular volume ( 27863252)
Interacting Genes		53 interacting genes: ADAP1 ADAP2 CD3E CD3EAP CDK1 CDKN2A CLK1 CSNK2A1 CSNK2A2 ERG ESR1 ETS1 FMR1 GRB2 GZF1 GZMA H1-2 H2AC20 H2AX H2BC21 H3-4 HMGA1 IL7R MDC1 MDK MDM2 MYB MYBL1 NBN NDRG1 NPM1 NR3C1 PARP1 PPARGC1A PPM1D PRKCZ PRMT5 PTGS1 RAD51 S100A11 SREK1 SRPK2 SSB STAU1 TERF2 TERT TOP1 TP53 VHL XRCC6 YWHAQ ZFP36 ZNF689	9 interacting genes: APP EEF1G IKBKG NCL NEDD4L PRNP RANBP9 SNCA TUBB
Entrez ID		4691	55803
HPRD ID		01245	16357
Ensembl ID		ENSG00000115053	ENSG00000184060
Uniprot IDs		B3KM80 P19338	Q2V6Q1 Q9NPF8
PDB IDs		2FC8 2FC9 2KRR
Enriched GO Terms of Interacting Partners?
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