SERPINC1 and KLK2

Number of citations of the paper that reports this interaction (PubMedID 9428387)
10

Data Source:
HPRD (in vitro)

		SERPINC1	KLK2
Description		serpin family C member 1	kallikrein related peptidase 2
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Plasma Membrane Collagen-containing Extracellular Matrix Extracellular Exosome Blood Microparticle	Extracellular Region Secretory Granule Extracellular Exosome
	Molecular Function	Protease Binding Serine-type Endopeptidase Inhibitor Activity Protein Binding Heparin Binding Identical Protein Binding	Serine-type Endopeptidase Activity
	Biological Process	Acute Inflammatory Response To Antigenic Stimulus Response To Nutrient Lactation Blood Coagulation Negative Regulation Of Endopeptidase Activity Post-translational Protein Modification Cellular Protein Metabolic Process Regulation Of Blood Coagulation, Intrinsic Pathway	Regulation Of Systemic Arterial Blood Pressure Extracellular Matrix Disassembly Zymogen Activation
Pathways		Intrinsic Pathway of Fibrin Clot Formation Common Pathway of Fibrin Clot Formation Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation	Activation of Matrix Metalloproteinases Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Drugs		Ardeparin Fondaparinux sodium Heparin Enoxaparin N-Formylmethionine SR-123781A Sulodexide Dalteparin Tinzaparin Nadroparin Copper Antithrombin III human
Diseases		Inherited thrombophilia
GWAS		Experiencing mood swings ( 29500382) Heel bone mineral density ( 30598549)	Celiac disease ( 23936387) PCA3 expression level ( 23555189) Prostate cancer ( 31562322) Prostate-specific antigen levels ( 23359319 28139693) Prostate-specific antigen levels (conditioned on lead SNPs) ( 28139693) Tandem gait ( 26219847)
Interacting Genes		6 interacting genes: ATP1B1 F2 KLK2 KLK6 PLG SDC2	14 interacting genes: A2M APP AR IGFBP2 POLR2A SEMG1 SEMG2 SERPINA3 SERPINA4 SERPINA5 SERPINB6 SERPINC1 SERPINE1 SERPINF2
Entrez ID		462	3817
HPRD ID		00122	01006
Ensembl ID		ENSG00000117601	ENSG00000167751
Uniprot IDs		A0A024R944 P01008	A0A024R4J4 A0A024R4N3 B4DU77 P20151
PDB IDs		1ANT 1ATH 1AZX 1BR8 1DZG 1DZH 1E03 1E04 1E05 1JVQ 1LK6 1NQ9 1OYH 1R1L 1SR5 1T1F 1TB6 2ANT 2B4X 2B5T 2BEH 2GD4 2HIJ 2ZNH 3EVJ 3KCG 4EB1	4NFE 4NFF
Enriched GO Terms of Interacting Partners?
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