GADD45B and MAP3K4

Number of citations of the paper that reports this interaction (PubMedID 9827804)
189

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		GADD45B	MAP3K4
Description		growth arrest and DNA damage inducible beta	mitogen-activated protein kinase kinase kinase 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm	Cytoplasm Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding	Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Metal Ion Binding
	Biological Process	Activation Of MAPKKK Activity Activation Of MAPKK Activity Negative Regulation Of Protein Kinase Activity Apoptotic Process Multicellular Organism Development Cell Differentiation Positive Regulation Of Apoptotic Process Positive Regulation Of JNK Cascade Regulation Of Cell Cycle Positive Regulation Of P38MAPK Cascade	MAPK Cascade Activation Of MAPKK Activity Placenta Development Regulation Of Mitotic Cell Cycle Response To UV-C Regulation Of Gene Expression Male Germ-line Sex Determination Signal Transduction By Protein Phosphorylation Stress-activated Protein Kinase Signaling Cascade Activation Of Protein Kinase Activity Positive Regulation Of Telomere Maintenance Via Telomerase Intracellular Signal Transduction Positive Regulation Of JUN Kinase Activity Positive Regulation Of Telomerase Activity Chorionic Trophoblast Cell Differentiation Positive Regulation Of P38MAPK Cascade Positive Regulation Of Telomere Capping
Pathways
Drugs
Diseases
GWAS			Aging ( 22773346) Blood protein levels ( 28240269) Cognitive decline rate in late mild cognitive impairment ( 26252872) Lipoprotein (a) levels ( 26377243) Ovarian disease with few adhesions ( 28333195)
Interacting Genes		13 interacting genes: CCNB1 CDK1 CDKN1A ESR1 GADD45G GADD45GIP1 MAP2K7 MAP3K4 MAP3K5 PCNA PPARA PPARD PPARG	26 interacting genes: ANXA2 AXIN1 BUB1B CDC42 CHUK CNTRL DIXDC1 GADD45A GADD45B GADD45G GSK3B MAP2K1 MAP2K3 MAP2K4 MAP2K6 MAP2K7 MAPK13 MFHAS1 PTK2B PTPN11 RAC1 RACGAP1 RUNX2 TPR TRAF4 YWHAZ
Entrez ID		4616	4216
HPRD ID		05382	03886
Ensembl ID		ENSG00000099860	ENSG00000085511
Uniprot IDs		K7EPQ8 O75293	Q9P1M2 Q9Y6R4
PDB IDs
Enriched GO Terms of Interacting Partners?
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