MYBPC3 and NCF1

Number of citations of the paper that reports this interaction (PubMedID 16052631)
35

Data Source:
BioGRID (two hybrid)

		MYBPC3	NCF1
Description		myosin binding protein C3	neutrophil cytosolic factor 1
Image
GO Annotations	Cellular Component	Cytosol Striated Muscle Myosin Thick Filament C Zone Sarcomere A Band Cardiac Myofibril	Cell Rough Endoplasmic Reticulum Golgi Apparatus Cytosol Plasma Membrane Membrane Extrinsic Component Of Membrane Dendrite Phagolysosome NADPH Oxidase Complex Neuronal Cell Body
	Molecular Function	ATPase Activator Activity Actin Binding Protein Binding Structural Constituent Of Muscle Myosin Binding Titin Binding Myosin Heavy Chain Binding Identical Protein Binding Metal Ion Binding	Protein Binding Electron Transfer Activity Superoxide-generating NADPH Oxidase Activity Superoxide-generating NADPH Oxidase Activator Activity SH3 Domain Binding Phosphatidylinositol Binding Phosphatidylinositol-3,4-bisphosphate Binding
	Biological Process	Heart Morphogenesis Regulation Of Striated Muscle Contraction Cell Adhesion Muscle Filament Sliding Positive Regulation Of ATPase Activity Regulation Of Muscle Filament Sliding Ventricular Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Contraction	Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Protein Targeting To Membrane Superoxide Metabolic Process Apoptotic Process Cellular Defense Response Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Electron Transport Chain Cellular Response To Oxidative Stress Cellular Response To Reactive Oxygen Species Superoxide Anion Generation Innate Immune Response Cell Redox Homeostasis Respiratory Burst Positive Regulation Of Epidermal Growth Factor-activated Receptor Activity Positive Regulation Of Transcription, DNA-templated Positive Regulation Of JNK Cascade Vascular Endothelial Growth Factor Receptor Signaling Pathway Cellular Response To Cadmium Ion Positive Regulation Of P38MAPK Cascade
Pathways		Striated Muscle Contraction	ROS and RNS production in phagocytes Cross-presentation of particulate exogenous antigens (phagosomes) Detoxification of Reactive Oxygen Species VEGFA-VEGFR2 Pathway RHO GTPases Activate NADPH Oxidases
Drugs			Dextromethorphan
Diseases		Hypertrophic cardiomyopathy (HCM) Dilated cardiomyopathy (DCM)	Chronic granulomatous disease, including the following four diseases: X-linked CGD (gp91 phox CGD); p22phox deficiency (p22phox CGD); p47phox deficiency (p47phox CGD); p67phox deficiency (p67phox CGD)
GWAS		Alcohol consumption ( 31358974) Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Autism spectrum disorder or schizophrenia ( 28540026) Experiencing mood swings ( 29500382) HDL cholesterol levels ( 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Intraocular pressure ( 30054594) Loneliness ( 29970889) Loneliness (MTAG) ( 29970889) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Multiple sclerosis ( 31604244) Neuroticism ( 29255261) Pulse pressure ( 30578418) Thrombin generation potential phenotypes ( 24357727) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716)
Interacting Genes		8 interacting genes: CAPN1 HSPB2 MYH9 NCF1 TNNI3K TRIM55 TRIM63 TTN	26 interacting genes: ACTB CSNK2B CYBA FASLG GAA GMNN KHDRBS1 MAPK9 MGAM MSN MYBPC1 MYBPC3 NCF4 NOXA1 PKD1 PLA2G4A PRKCA PRKCB PRKCD PRKCZ PRKDC PTEN SRSF2 SYTL1 TRAF4 TRIM9
Entrez ID		4607	653361
HPRD ID		02980
Ensembl ID		ENSG00000134571	ENSG00000158517
Uniprot IDs		A5YM48 Q14896	P14598
PDB IDs		1GXE 1PD6 2AVG 2K1M 2MQ0 2MQ3 2V6H 3CX2 5K6P 6CXI 6CXJ 6G2T	1GD5 1K4U 1KQ6 1NG2 1O7K 1OV3 1UEC 1W70 1WLP
Enriched GO Terms of Interacting Partners?
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