NCF1 and MYBPC1

Number of citations of the paper that reports this interaction (PubMedID 16052631)
35

Data Source:
BioGRID (two hybrid)

		NCF1	MYBPC1
Description		neutrophil cytosolic factor 1	myosin binding protein C1
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GO Annotations	Cellular Component	Cell Rough Endoplasmic Reticulum Golgi Apparatus Cytosol Plasma Membrane Membrane Extrinsic Component Of Membrane Dendrite Phagolysosome NADPH Oxidase Complex Neuronal Cell Body	Cytosol Myofibril Myosin Filament
	Molecular Function	Protein Binding Electron Transfer Activity Superoxide-generating NADPH Oxidase Activity Superoxide-generating NADPH Oxidase Activator Activity SH3 Domain Binding Phosphatidylinositol Binding Phosphatidylinositol-3,4-bisphosphate Binding	Actin Binding Protein Binding Structural Constituent Of Muscle Titin Binding
	Biological Process	Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Protein Targeting To Membrane Superoxide Metabolic Process Apoptotic Process Cellular Defense Response Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Electron Transport Chain Cellular Response To Oxidative Stress Cellular Response To Reactive Oxygen Species Superoxide Anion Generation Innate Immune Response Cell Redox Homeostasis Respiratory Burst Positive Regulation Of Epidermal Growth Factor-activated Receptor Activity Positive Regulation Of Transcription, DNA-templated Positive Regulation Of JNK Cascade Vascular Endothelial Growth Factor Receptor Signaling Pathway Cellular Response To Cadmium Ion Positive Regulation Of P38MAPK Cascade	Cell Adhesion Muscle Filament Sliding
Pathways		ROS and RNS production in phagocytes Cross-presentation of particulate exogenous antigens (phagosomes) Detoxification of Reactive Oxygen Species VEGFA-VEGFR2 Pathway RHO GTPases Activate NADPH Oxidases	Striated Muscle Contraction
Drugs		Dextromethorphan
Diseases		Chronic granulomatous disease, including the following four diseases: X-linked CGD (gp91 phox CGD); p22phox deficiency (p22phox CGD); p47phox deficiency (p47phox CGD); p67phox deficiency (p67phox CGD)
GWAS			Blood protein levels ( 28240269) Lung function (FEV1) ( 24023788)
Interacting Genes		26 interacting genes: ACTB CSNK2B CYBA FASLG GAA GMNN KHDRBS1 MAPK9 MGAM MSN MYBPC1 MYBPC3 NCF4 NOXA1 PKD1 PLA2G4A PRKCA PRKCB PRKCD PRKCZ PRKDC PTEN SRSF2 SYTL1 TRAF4 TRIM9	10 interacting genes: CALM1 FHL1 FHL2 FHL3 MEOX2 NCF1 RAF1 TRIM55 TRIM63 TTN
Entrez ID		653361	4604
HPRD ID			01185
Ensembl ID		ENSG00000158517	ENSG00000196091
Uniprot IDs		P14598	A8KAB1 B3KPP3 Q00872 Q86TA8
PDB IDs		1GD5 1K4U 1KQ6 1NG2 1O7K 1OV3 1UEC 1W70 1WLP	1X44 2DAV 2YUV 2YUW 2YUX 2YUZ 2YXM
Enriched GO Terms of Interacting Partners?
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