ASPH and GET3

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		ASPH	GET3
Description		aspartate beta-hydroxylase	guided entry of tail-anchored proteins factor 3, ATPase
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Membrane Cortical Endoplasmic Reticulum Sarcoplasmic Reticulum Membrane	Nucleoplasm Nucleolus Cytoplasm Endoplasmic Reticulum Membrane GET Complex Extracellular Exosome
	Molecular Function	Peptide-aspartate Beta-dioxygenase Activity Structural Molecule Activity Calcium Ion Binding Protein Binding Structural Constituent Of Muscle Electron Transfer Activity	Protein Binding ATP Binding Arsenite Transmembrane Transporter Activity ATPase Activity Metal Ion Binding
	Biological Process	Muscle Contraction Pattern Specification Process Negative Regulation Of Cell Proliferation Electron Transport Chain Regulation Of Protein Stability Ion Transmembrane Transport Limb Morphogenesis Peptidyl-aspartic Acid Hydroxylation Positive Regulation Of Proteolysis Roof Of Mouth Development Face Morphogenesis Activation Of Cysteine-type Endopeptidase Activity Regulation Of Protein Depolymerization Regulation Of Cardiac Conduction	Posttranslational Protein Targeting To Endoplasmic Reticulum Membrane Arsenite Transport IRE1-mediated Unfolded Protein Response Tail-anchored Membrane Protein Insertion Into ER Membrane
Pathways		Stimuli-sensing channels Ion homeostasis	Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Drugs		L-Aspartic Acid Succinic acid	ATP
Diseases
GWAS		Blood protein levels ( 30072576 29875488) BRCA1/2-negative high-risk breast cancer ( 30323354) Resting heart rate ( 28270201) Urate levels in overweight individuals ( 25811787)
Interacting Genes		5 interacting genes: APP FBXO7 GET3 RAB2A TRDN	14 interacting genes: APLN ASPH CACNA1A GET4 GPX7 HILPDA PFDN1 SEC61A1 SEC61B STATH STX5 TK1 TTR VAMP2
Entrez ID		444	439
HPRD ID		08996	03555
Ensembl ID		ENSG00000198363	ENSG00000198356
Uniprot IDs		B4DQ07 B7ZM96 Q12797	O43681
PDB IDs		5APA 5JQY 5JTC 5JZ6 5JZ8 5JZA 5JZU 6RK9
Enriched GO Terms of Interacting Partners?
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