MSH3 and XPA

Number of citations of the paper that reports this interaction (PubMedID 19468048)
38

Data Source:
BioGRID (pull down)

		MSH3	XPA
Description		mutS homolog 3	XPA, DNA damage recognition and repair factor
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Membrane Mismatch Repair Complex MutSbeta Complex	Nucleotide-excision Repair Factor 1 Complex Nucleus Nucleoplasm DNA Replication Factor A Complex Cytoplasm Intercellular Bridge
	Molecular Function	Single-stranded DNA Binding Protein Binding DNA-dependent ATPase Activity Enzyme Binding Mismatched DNA Binding DNA Insertion Or Deletion Binding Guanine/thymine Mispair Binding Dinucleotide Insertion Or Deletion Binding Single Guanine Insertion Binding Dinucleotide Repeat Insertion Binding Oxidized Purine DNA Binding Protein Homodimerization Activity	Damaged DNA Binding Protein Binding Protein Domain Specific Binding Protein Homodimerization Activity Metal Ion Binding
	Biological Process	Meiotic Mismatch Repair Removal Of Nonhomologous Ends DNA Repair Mismatch Repair Mitotic Recombination Reciprocal Meiotic Recombination Somatic Recombination Of Immunoglobulin Gene Segments Replication Fork Arrest Maintenance Of DNA Repeat Elements Negative Regulation Of DNA Recombination Positive Regulation Of Helicase Activity	Nucleotide-excision Repair, DNA Damage Recognition Nucleotide-excision Repair, DNA Duplex Unwinding DNA Repair Transcription-coupled Nucleotide-excision Repair Base-excision Repair Nucleotide-excision Repair, Preincision Complex Stabilization Nucleotide-excision Repair, Preincision Complex Assembly Nucleotide-excision Repair, DNA Incision, 3'-to Lesion Nucleotide-excision Repair, DNA Incision, 5'-to Lesion Response To Oxidative Stress Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To Toxic Substance UV Protection Regulation Of Autophagy Response To Auditory Stimulus Nucleotide-excision Repair, DNA Incision Protein Localization To Nucleus Multicellular Organism Growth Positive Regulation Of Transcription Initiation From RNA Polymerase II Promoter Global Genome Nucleotide-excision Repair UV-damage Excision Repair Nucleotide-excision Repair Involved In Interstrand Cross-link Repair
Pathways		Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Defective Mismatch Repair Associated With MSH3 Defective Mismatch Repair Associated With MSH2	Formation of Incision Complex in GG-NER Dual Incision in GG-NER Formation of TC-NER Pre-Incision Complex Dual incision in TC-NER
Drugs
Diseases		Colorectal cancer	Disorders of nucleotide excision repair, including: Xeroderma pigmentosum (XP); Cockayne syndrome (CS); UV-sensitive syndrome (UVS); Trichothiodystrophy (TTD); Cerebro-oculo-facio-skeletal syndrome (COFS); XFE progeroid syndrome
GWAS		HDL cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931) Huntington's disease progression ( 28642124)	Hypothyroidism ( 27182965) Obesity-related traits ( 23251661) Serum thyroid-stimulating hormone levels ( 24852370) Thyroid cancer (Papillary, radiation-related) ( 20350937)
Interacting Genes		13 interacting genes: BARD1 BRCA1 EXO1 HUS1 MLH1 MSH2 PCNA RAD1 RAD9A RCHY1 RPA4 TSC22D2 XPA	25 interacting genes: AP2M1 ATM ATR DDB1 DDB2 ERCC1 ERCC4 ERCC6 GPN1 GTF2E2 GTF2H1 HERC2 MSH2 MSH3 NDEL1 PCNA PRKDC RASSF1 RHOU RPA1 RPA2 RPA4 TRIM27 XAB2 XPC
Entrez ID		4437	7507
HPRD ID		02931	02045
Ensembl ID		ENSG00000113318	ENSG00000136936
Uniprot IDs		P20585	P23025
PDB IDs		3THW 3THX 3THY 3THZ	1D4U 1XPA 2JNW 6J44 6RO4
Enriched GO Terms of Interacting Partners?
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