MMP1 and TIMP1

Number of citations of the paper that reports this interaction (PubMedID 9063449)
6

Data Source:
HPRD (in vivo)

		MMP1	TIMP1
Description		matrix metallopeptidase 1	TIMP metallopeptidase inhibitor 1
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Matrix	Extracellular Region Basement Membrane Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix Platelet Alpha Granule Lumen Extracellular Exosome
	Molecular Function	Endopeptidase Activity Metalloendopeptidase Activity Serine-type Endopeptidase Activity Peptidase Activity Zinc Ion Binding	Protease Binding Cytokine Activity Protein Binding Growth Factor Activity Metalloendopeptidase Inhibitor Activity Zinc Ion Binding Peptidase Inhibitor Activity
	Biological Process	Proteolysis Viral Process Cytokine-mediated Signaling Pathway Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process Positive Regulation Of Protein Complex Assembly Cellular Protein Metabolic Process Leukocyte Migration	Cell Activation Connective Tissue Replacement Involved In Inflammatory Response Wound Healing Platelet Degranulation Aging Positive Regulation Of Cell Proliferation Response To Hormone Response To Organic Substance Negative Regulation Of Endopeptidase Activity Cytokine-mediated Signaling Pathway Extracellular Matrix Disassembly Response To Cytokine Negative Regulation Of Apoptotic Process Negative Regulation Of Catalytic Activity Response To Peptide Hormone Post-translational Protein Modification Cellular Protein Metabolic Process Negative Regulation Of Membrane Protein Ectodomain Proteolysis Cartilage Development Negative Regulation Of Trophoblast Cell Migration Negative Regulation Of Metallopeptidase Activity Regulation Of Integrin-mediated Signaling Pathway
Pathways		Collagen degradation Collagen degradation Degradation of the extracellular matrix Degradation of the extracellular matrix Activation of Matrix Metalloproteinases Basigin interactions Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Interleukin-4 and Interleukin-13 signaling	Platelet degranulation Activation of Matrix Metalloproteinases Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Post-translational protein phosphorylation
Drugs		Marimastat N-HYDROXY-2(R)-[[(4-METHOXYPHENYL)SULFONYL](3-PICOLYL)AMINO]-3-METHYLBUTANAMIDE HYDROCHLORIDE N-[3-(N'-HYDROXYCARBOXAMIDO)-2-(2-METHYLPROPYL)-PROPANOYL]-O-TYROSINE-N-METHYLAMIDE METHYLAMINO-PHENYLALANYL-LEUCYL-HYDROXAMIC ACID [[1-[N-HYDROXY-ACETAMIDYL]-3-METHYL-BUTYL]-CARBONYL-LEUCINYL]-ALANINE ETHYL ESTER N-HYDROXY-2-[4-(4-PHENOXY-BENZENESULFONYL)-TETRAHYDRO-PYRAN-4-YL]-ACETAMIDE
Diseases		Choriocarcinoma
GWAS		Blood protein levels ( 30072576 28240269) Blood protein levels in cardiovascular risk ( 28369058)
Interacting Genes		17 interacting genes: ACAN BCAN BSG CCL13 CCL2 CCL7 CD44 CMA1 COL2A1 IGFBP3 ITGA2 MMP7 SERPINA3 SOX8 TFPI TIMP1 TNFSF11	9 interacting genes: CD63 ECH1 EEF1B2 MMP1 MMP14 MMP2 MMP3 MYOC RECQL5
Entrez ID		4312	7076
HPRD ID		00384	02371
Ensembl ID		ENSG00000196611	ENSG00000102265
Uniprot IDs		B4DN15 P03956 Q53G95	B4DJK3 P01033 Q6FGX5
PDB IDs		1AYK 1CGE 1CGF 1CGL 1HFC 1SU3 2AYK 2CLT 2J0T 2TCL 3AYK 3SHI 4AUO 4AYK 966C	1D2B 1LQN 1OO9 1UEA 2J0T 3MA2 3V96 6MAV 6N9D
Enriched GO Terms of Interacting Partners?
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