MMP1 and SOX8

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		MMP1	SOX8
Description		matrix metallopeptidase 1	SRY-box transcription factor 8
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Matrix	Nuclear Chromatin Nucleus Cytoplasm Nuclear Transcription Factor Complex
	Molecular Function	Endopeptidase Activity Metalloendopeptidase Activity Serine-type Endopeptidase Activity Peptidase Activity Zinc Ion Binding	RNA Polymerase II Core Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Transcription Factor Binding
	Biological Process	Proteolysis Viral Process Cytokine-mediated Signaling Pathway Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process Positive Regulation Of Protein Complex Assembly Cellular Protein Metabolic Process Leukocyte Migration	Negative Regulation Of Transcription By RNA Polymerase II Osteoblast Differentiation In Utero Embryonic Development Neural Crest Cell Migration Morphogenesis Of An Epithelium Signal Transduction Spermatogenesis Peripheral Nervous System Development Male Gonad Development Regulation Of Hormone Levels Positive Regulation Of Gliogenesis Neural Crest Cell Development Positive Regulation Of Osteoblast Proliferation Skeletal Muscle Cell Differentiation Negative Regulation Of Apoptotic Process Cell Fate Commitment Fat Cell Differentiation Negative Regulation Of Myoblast Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Photoreceptor Cell Differentiation Cell Maturation Enteric Nervous System Development Oligodendrocyte Differentiation Sertoli Cell Development Astrocyte Fate Commitment Retina Development In Camera-type Eye Retinal Rod Cell Differentiation Adipose Tissue Development Morphogenesis Of A Branching Epithelium Renal Vesicle Induction Ureter Morphogenesis Metanephric Nephron Tubule Formation Positive Regulation Of Kidney Development Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis
Pathways		Collagen degradation Collagen degradation Degradation of the extracellular matrix Degradation of the extracellular matrix Activation of Matrix Metalloproteinases Basigin interactions Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Interleukin-4 and Interleukin-13 signaling
Drugs		Marimastat N-HYDROXY-2(R)-[[(4-METHOXYPHENYL)SULFONYL](3-PICOLYL)AMINO]-3-METHYLBUTANAMIDE HYDROCHLORIDE N-[3-(N'-HYDROXYCARBOXAMIDO)-2-(2-METHYLPROPYL)-PROPANOYL]-O-TYROSINE-N-METHYLAMIDE METHYLAMINO-PHENYLALANYL-LEUCYL-HYDROXAMIC ACID [[1-[N-HYDROXY-ACETAMIDYL]-3-METHYL-BUTYL]-CARBONYL-LEUCINYL]-ALANINE ETHYL ESTER N-HYDROXY-2-[4-(4-PHENOXY-BENZENESULFONYL)-TETRAHYDRO-PYRAN-4-YL]-ACETAMIDE
Diseases		Choriocarcinoma
GWAS		Blood protein levels ( 30072576 28240269) Blood protein levels in cardiovascular risk ( 28369058)	Logical memory (immediate recall) in normal cognition ( 29274321) Multiple sclerosis ( 31604244 21833088) Polycystic ovary syndrome ( 25574032)
Interacting Genes		17 interacting genes: ACAN BCAN BSG CCL13 CCL2 CCL7 CD44 CMA1 COL2A1 IGFBP3 ITGA2 MMP7 SERPINA3 SOX8 TFPI TIMP1 TNFSF11	18 interacting genes: CEBPA DLX5 EGR2 HHEX HOXC11 JAM2 JUN MMP1 NOD1 NR5A1 OLIG2 PAX3 PIDD1 POU3F3 POU5F1 SP1 TCF12 UTF1
Entrez ID		4312	30812
HPRD ID		00384	16175
Ensembl ID		ENSG00000196611	ENSG00000005513
Uniprot IDs		B4DN15 P03956 Q53G95	P57073
PDB IDs		1AYK 1CGE 1CGF 1CGL 1HFC 1SU3 2AYK 2CLT 2J0T 2TCL 3AYK 3SHI 4AUO 4AYK 966C
Enriched GO Terms of Interacting Partners?
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