NR3C2 and FKBP4

Number of citations of the paper that reports this interaction (PubMedID 20661446)
35

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro)

		NR3C2	FKBP4
Description		nuclear receptor subfamily 3 group C member 2	FKBP prolyl isomerase 4
Image
GO Annotations	Cellular Component	Nuclear Chromatin Nucleoplasm Endoplasmic Reticulum Membrane Cytosol Receptor Complex	Nucleoplasm Cytoplasm Mitochondrion Cytosol Microtubule Protein-containing Complex Neuronal Cell Body Axonal Growth Cone Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Steroid Hormone Receptor Activity Steroid Binding Protein Binding Zinc Ion Binding Sequence-specific DNA Binding	RNA Binding Peptidyl-prolyl Cis-trans Isomerase Activity Protein Binding ATP Binding GTP Binding FK506 Binding Protein Binding, Bridging Heat Shock Protein Binding Copper-dependent Protein Binding Glucocorticoid Receptor Binding Tau Protein Binding Phosphoprotein Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Signal Transduction Steroid Hormone Mediated Signaling Pathway Positive Regulation Of NIK/NF-kappaB Signaling	Protein Peptidyl-prolyl Isomerization Protein Folding Steroid Hormone Receptor Complex Assembly Copper Ion Transport Embryo Implantation Negative Regulation Of Neuron Projection Development Androgen Receptor Signaling Pathway Prostate Gland Development Negative Regulation Of Microtubule Polymerization Or Depolymerization Negative Regulation Of Microtubule Polymerization Protein-containing Complex Localization Male Sex Differentiation Chaperone-mediated Protein Folding Regulation Of Cellular Response To Heat
Pathways		HSP90 chaperone cycle for steroid hormone receptors (SHR) SUMOylation of intracellular receptors	HSP90 chaperone cycle for steroid hormone receptors (SHR) Attenuation phase ESR-mediated signaling Estrogen-dependent gene expression
Drugs		Nimodipine Progesterone Spironolactone Fluticasone propionate Testosterone Fludrocortisone Eplerenone Felodipine Desoxycorticosterone Pivalate Drospirenone Dihydrotestosterone Methyltrienolone Aldosterone Corticosterone
Diseases		Hyperkalemic distal renal tubular acidosis (RTA type 4), including the following two diseases: Pseudohypoaldosteronism type I (PHA1); Pseudohypoaldosteronism type II (Gordon's syndrome) Hypertension exacerbated in pregnancy
GWAS		Alzheimer disease and age of onset ( 26830138) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Biochemical measures ( 19260141) Blond vs. brown/black hair color ( 30531825) Central corneal thickness ( 29760442) Corneal structure ( 23291589) Hippocampal volume ( 31530798) Hypothyroidism ( 27182965) Microalbuminuria ( 31511532) Plasma thyroid-stimulating hormone levels ( 28333968) Subcutaneous adipose tissue ( 22589738) Thyroid function ( 22494929) Thyroid hormone levels ( 23408906) Thyroid stimulating hormone levels ( 25743335) Urinary albumin excretion ( 30220432) Urinary albumin excretion (no hypertensive medication) ( 30220432) Urinary albumin-to-creatinine ratio ( 31630189 31511532) Vestibular neuritis ( 30079052)	FEV1 ( 30804560) Lung function (FVC) ( 30804560) Peak expiratory flow ( 30804560) Quantitative traits ( 19197348)
Interacting Genes		20 interacting genes: ACSL1 ACTA1 ACTG1 AR CASP8AP2 FKBP4 HSP90AA1 HSPA4 NCOA1 NR3C1 PIAS1 PIAS3 PROX1 PSMC5 PTGES3 RABAC1 RXRA SUMO1 TRIM24 UBE2I	26 interacting genes: ACVR1 AHSA1 ATOX1 CALM1 CSNK2A1 EGFR ESR1 FES FKBP1A GLMN HSF1 HSP90AA1 HSPA4 IRF4 NR3C1 NR3C2 PHYH PTPN2 S100A1 S100A2 S100A6 SH3BP4 SMURF2 SNCA SQSTM1 STIP1
Entrez ID		4306	2288
HPRD ID		02991	11794
Ensembl ID		ENSG00000151623	ENSG00000004478
Uniprot IDs		B0ZBF6 P08235	Q02790
PDB IDs		1Y9R 1YA3 2A3I 2AA2 2AA5 2AA6 2AA7 2AAX 2AB2 2ABI 2OAX 3VHU 3VHV 3WFF 3WFG 4PF3 4TNT 4UDA 4UDB 5HCV 5L7E 5L7G 5L7H 5MWP 5MWY 6GEV 6GG8 6GGG	1N1A 1P5Q 1Q1C 1QZ2 4DRJ 4LAV 4LAW 4LAX 4LAY 4TW8
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?