NR3C2 and ACSL1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		NR3C2	ACSL1
Description		nuclear receptor subfamily 3 group C member 2	acyl-CoA synthetase long chain family member 1
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleoplasm Endoplasmic Reticulum Membrane Cytosol Receptor Complex	Mitochondrion Mitochondrial Outer Membrane Peroxisomal Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane Integral Component Of Membrane
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Steroid Hormone Receptor Activity Steroid Binding Protein Binding Zinc Ion Binding Sequence-specific DNA Binding	Acyl-CoA Ligase Activity Long-chain Fatty Acid-CoA Ligase Activity ATP Binding Arachidonate-CoA Ligase Activity Phytanate-CoA Ligase Activity Decanoate-CoA Ligase Activity
	Biological Process	Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Signal Transduction Steroid Hormone Mediated Signaling Pathway Positive Regulation Of NIK/NF-kappaB Signaling	Very Long-chain Fatty Acid Metabolic Process Long-chain Fatty Acid Metabolic Process Response To Nutrient Lipid Biosynthetic Process Response To Organic Cyclic Compound Regulation Of Lipid Metabolic Process Triglyceride Biosynthetic Process Adiponectin-activated Signaling Pathway Response To Oleic Acid Long-chain Fatty-acyl-CoA Biosynthetic Process Alpha-linolenic Acid Metabolic Process Xenobiotic Catabolic Process Response To Drug Linoleic Acid Metabolic Process Long-chain Fatty Acid Import Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Cold-induced Thermogenesis
Pathways		HSP90 chaperone cycle for steroid hormone receptors (SHR) SUMOylation of intracellular receptors	PPARA activates gene expression Linoleic acid (LA) metabolism alpha-linolenic acid (ALA) metabolism Synthesis of very long-chain fatty acyl-CoAs
Drugs		Nimodipine Progesterone Spironolactone Fluticasone propionate Testosterone Fludrocortisone Eplerenone Felodipine Desoxycorticosterone Pivalate Drospirenone Dihydrotestosterone Methyltrienolone Aldosterone Corticosterone	Adenosine monophosphate ATP
Diseases		Hyperkalemic distal renal tubular acidosis (RTA type 4), including the following two diseases: Pseudohypoaldosteronism type I (PHA1); Pseudohypoaldosteronism type II (Gordon's syndrome) Hypertension exacerbated in pregnancy
GWAS		Alzheimer disease and age of onset ( 26830138) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Biochemical measures ( 19260141) Blond vs. brown/black hair color ( 30531825) Central corneal thickness ( 29760442) Corneal structure ( 23291589) Hippocampal volume ( 31530798) Hypothyroidism ( 27182965) Microalbuminuria ( 31511532) Plasma thyroid-stimulating hormone levels ( 28333968) Subcutaneous adipose tissue ( 22589738) Thyroid function ( 22494929) Thyroid hormone levels ( 23408906) Thyroid stimulating hormone levels ( 25743335) Urinary albumin excretion ( 30220432) Urinary albumin excretion (no hypertensive medication) ( 30220432) Urinary albumin-to-creatinine ratio ( 31630189 31511532) Vestibular neuritis ( 30079052)	Fulminant type 1 diabetes ( 30552108) Night sleep phenotypes ( 27126917) Type 2 diabetes ( 28566273 30054458 30297969)
Interacting Genes		20 interacting genes: ACSL1 ACTA1 ACTG1 AR CASP8AP2 FKBP4 HSP90AA1 HSPA4 NCOA1 NR3C1 PIAS1 PIAS3 PROX1 PSMC5 PTGES3 RABAC1 RXRA SUMO1 TRIM24 UBE2I	1 interacting genes: NR3C2
Entrez ID		4306	2180
HPRD ID		02991	01068
Ensembl ID		ENSG00000151623	ENSG00000151726
Uniprot IDs		B0ZBF6 P08235	A8K9T3 B4E0R0 B7Z3Z9 E7EPM6 P33121
PDB IDs		1Y9R 1YA3 2A3I 2AA2 2AA5 2AA6 2AA7 2AAX 2AB2 2ABI 2OAX 3VHU 3VHV 3WFF 3WFG 4PF3 4TNT 4UDA 4UDB 5HCV 5L7E 5L7G 5L7H 5MWP 5MWY 6GEV 6GG8 6GGG
Enriched GO Terms of Interacting Partners?
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