MEOX2 and IL1A

Number of citations of the paper that reports this interaction (PubMedID 25910212)
127

Data Source:
BioGRID (two hybrid)

		MEOX2	IL1A
Description		mesenchyme homeobox 2	interleukin 1 alpha
Image		No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Cytoplasm Nuclear Speck	Extracellular Region Extracellular Space Cytosol
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding	Cytokine Activity Interleukin-1 Receptor Binding Copper Ion Binding Protein Binding
	Biological Process	Angiogenesis Somite Specification Multicellular Organism Development Skeletal Muscle Tissue Development Blood Circulation Positive Regulation Of Transcription By RNA Polymerase II Roof Of Mouth Development Limb Development Somite Development Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis	Fever Generation Connective Tissue Replacement Involved In Inflammatory Response Wound Healing Inflammatory Response To Antigenic Stimulus Apoptotic Process Inflammatory Response Negative Regulation Of Cell Proliferation Positive Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Gene Expression Cytokine-mediated Signaling Pathway Cellular Response To Heat Ectopic Germ Cell Programmed Cell Death Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Interleukin-2 Biosynthetic Process Positive Regulation Of Angiogenesis Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Transcription By RNA Polymerase II Response To Copper Ion Positive Regulation Of Protein Secretion Positive Regulation Of Cytokine Secretion Positive Regulation Of Cell Division Interleukin-1-mediated Signaling Pathway Cellular Response To Lipopolysaccharide Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Interleukin-2 Secretion Positive Regulation Of Tumor Necrosis Factor Secretion Positive Regulation Of Interleukin-6 Secretion Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways			Senescence-Associated Secretory Phenotype (SASP) Interleukin-1 processing Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Interleukin-1 signaling Purinergic signaling in leishmaniasis infection
Drugs			Rilonacept
Diseases			Graft-versus-host disease
GWAS		Adolescent idiopathic scoliosis ( 31417091) Blood trace element (Zn levels) ( 23720494) Heel bone mineral density ( 30598549 28869591) Kidney function decline traits ( 25493955) Resting-state electroencephalogram vigilance ( 29703947) Total intracranial volume ( 31530798)	Dysmenorrheic pain severity ( 29855537) Endometriosis ( 20844546 28537267) Gestational age at birth (child effect) ( 31477735) Interleukin-1-receptor antagonist levels ( 22205395) Post-term birth ( 31477735) Response to antipsychotic treatment in schizophrenia (working memory) ( 21107309)
Interacting Genes		244 interacting genes: - ACBD4 ACTN4 ADAMTS12 AGPAT1 AHCYL1 AHSA2P AMMECR1 ANP32B ARHGEF7 ARNT2 ATG5 ATXN1L AXIN1 BANP BCL2L15 BTK C1orf109 CARD9 CASP14 CCDC103 CCNC CDH9 CEP57L1 CHIC2 CHRD CHRNG CIAPIN1 CIB3 CNTNAP2 COG7 CPNE6 CPSF4 CRCT1 CSDC2 CSF2 CTNNBL1 CXXC1 DGCR6 DGCR8 DOCK8 DYNLL2 EDF1 EFEMP1 EFEMP2 EFNA3 EIF1AD EIF5A EMD EPM2AIP1 ESR2 ESRRG FAM126A FAM13C FAM3A FAM74A4 FANCC FANCG FBF1 FBLN5 FGA FKBP6 FOXR1 FUCA2 FUT11 GABRB3 GAGE1 GINS3 GLO1 GMCL2 GMPR2 GNG11 GOLGA8DP GOLGA8EP GOLGA8F GPATCH2L GPSM3 HAT1 HDHD2 HEXIM2 HGF HLA-A HNRNPD HP1BP3 HSPA2 HTR1E IGF2BP3 IGFN1 IL1A INPP1 IP6K2 ITM2A KAT5 KDM8 KIZ KLC4 KLHL38 KRT80 KRT86 KRTAP10-1 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-8 KRTAP10-9 KRTAP12-1 KRTAP12-4 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-7 KRTAP5-6 KRTAP5-9 KRTAP9-2 KTN1 LAMTOR5 LCE1B LCE2A LCE4A LSM2 MAGED1 MAPKBP1 MCM7 MDFI METTL17 MKRN3 MLF1 MLLT6 MMP3 MOBP MORN3 MRFAP1L1 MSI2 MT-CO1 MT-ND1 MT1DP MTMR10 MVP MYBPC1 NAA10 NALCN NCALD NCK2 NLGN3 NTF3 OIT3 OSGIN1 P4HA3 PACSIN2 PAGE2 PAK1IP1 PARVG PAX1 PAX3 PCDH9 PCSK5 PGBD1 PIN1 PKIG POM121C PRKAB2 PRKN PRPF31 PRR19 PSMB10 PSMC1 PSMD14 PTGER3 PWWP3A RARB RBM10 RBM5 RCHY1 RECK RHOJ RMND5A RND2 RNF40 RNF6 RPL15 RUNX1T1 SAMM50 SCNM1 SEC63 SELENOP SET SHFL SIRPB1 SLC48A1 SMAD3 SMARCE1 SPATA1 SPP1 SPRY1 SPRY2 SSX3 STK16 STX11 STX16 STXBP1 SYT17 TBCEL TBL2 TBX6 TCEA2 TCL6 TCTEX1D1 TDO2 TGFB1 TICAM2 TMEM100 TP53BP1 TRAF6 TRIM41 TRIM42 TTC25 TTC39B TTC9C TULP2 TXLNA UBE3A UBL4A UBL4B UNC45A UPP2 USE1 VDR VEZF1 VIP WFDC9 XRCC2 ZBED4 ZCWPW1 ZMAT2 ZNF124 ZNF329 ZNF404 ZNF417 ZNF483 ZNF564 ZNF572 ZNF587 ZNF688 ZNF695	11 interacting genes: CAPN1 CASP1 HAX1 IL1R1 IL1R2 IL1RAP KPNA6 MEOX2 NDN NFKBIE S100A13
Entrez ID		4223	3552
HPRD ID		02760	00988
Ensembl ID		ENSG00000106511	ENSG00000115008
Uniprot IDs		P50222	P01583
PDB IDs			1ITA 2ILA 2KKI 2L5X 5UC6
Enriched GO Terms of Interacting Partners?
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