MAP3K1 and RNF126

Number of citations of the paper that reports this interaction (PubMedID 25260751)
10

Data Source:
BioGRID (enzymatic study)

		MAP3K1	RNF126
Description		mitogen-activated protein kinase kinase kinase 1	ring finger protein 126
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Zinc Ion Binding Protein Kinase Binding	Epidermal Growth Factor Receptor Binding Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	MAPK Cascade Activation Of MAPKK Activity MyD88-dependent Toll-like Receptor Signaling Pathway Protein Phosphorylation Regulation Of Mitotic Cell Cycle Signal Transduction By Protein Phosphorylation Stress-activated Protein Kinase Signaling Cascade Activation Of Protein Kinase Activity Fc-epsilon Receptor Signaling Pathway Cellular Response To Mechanical Stimulus	Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Protein Ubiquitination Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Cell Proliferation Retrograde Transport, Endosome To Golgi Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Cytoplasm Protein Quality Control By The Ubiquitin-proteasome System
Pathways		MyD88:MAL(TIRAP) cascade initiated on plasma membrane FCERI mediated MAPK activation FCERI mediated MAPK activation TRAF6 mediated NF-kB activation TRAF6 mediated NF-kB activation TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88 cascade initiated on plasma membrane	Antigen processing: Ubiquitination & Proteasome degradation
Drugs		AZD-8330
Diseases
GWAS		Alanine transaminase levels ( 29403010) Blond vs. brown/black hair color ( 30531825) Breast cancer ( 29059683 17529967 23535729 31757997 20453838 19330030) Breast cancer (early onset) ( 24493630) Brown vs. black hair color ( 30531825) Coronary artery disease ( 29212778) Fasting blood insulin ( 25631608) Fasting glucose in pregnancy (gestational week 14-16) ( 30324795) Fasting insulin (dietary factor interaction) ( 24204828) Homeostasis model assessment of insulin resistance (dietary factor interaction) ( 24204828) Initial pursuit acceleration ( 29064472) Lung function (FEV1) ( 30061609) Sexual dimorphism in anthropometric traits ( 23754948) Triglyceride levels ( 28334899) Triglycerides ( 24097068 20686565) Type 2 diabetes ( 23209189) Urate levels (BMI interaction) ( 25811787) Waist circumference ( 23966867) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412 28448500) Waist-hip ratio ( 25673412) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist-to-hip ratio adjusted for BMI (smoking interaction) ( 28443625) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for BMI in non-smokers ( 28443625) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) Waist-to-hip ratio adjusted for body mass index ( 25673412 28448500)	Arterial stiffness ( 31070453) Arterial stiffness index ( 31235810) Pulse pressure ( 30578418)
Interacting Genes		95 interacting genes: ACTN1 APEX2 APPL1 ARHGAP4 ASCC2 ATXN3 BAALC BAP1 BRCA1 CARD14 CCDC69 CD74 CEP85 CHUK COPS6 CRELD1 CRTC1 CUEDC1 DCUN1D1 DCUN1D2 DENND6B DNAJB2 DNAJB6 DTX1 EPHA1 EPN1 FAF2 FAM184A FKBP6 GGA2 GRIPAP1 GSK3B HBS1L HGS HIP1 IKBKB ILRUN IMPACT KRT36 MAP2K4 MAP2K7 MAPK1 MAPK9 MBP MINDY3 NEK10 NFKBIA NOTCH1 NPLOC4 NR4A1 ODF2 PAK1 PLEKHB2 PSMD4 RAB3IL1 RABEP2 RAD18 RAD23A RAD51AP1 RAF1 RBCK1 RIPK1 RNF114 RNF126 RNF141 SPART STAM STAM2 TAB1 TNIP1 TOM1 TOM1L2 TP53 UBAC1 UBAP1 UBASH3B UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2G1 UBE2I UBE2K UBE2L6 UBE2V1 UBE2W UBQLN1 UBXN7 UCHL5 UFD1 USP28 YWHAE ZFAND3 ZFAND5	34 interacting genes: AICDA BAG6 CDKN1A CSNK2B E2F1 EGFR FXN HMGCL MAP3K1 MDM2 NUDT3 OTUB1 OTUB2 PLK1 PSMF1 RBX1 RNF168 SNUPN TRIM11 TRIM23 TRIM26 TRIM52 TSG101 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2N UBL4A USP15 USP2 XRCC5 XRCC6
Entrez ID		4214	55658
HPRD ID		19599	11501
Ensembl ID		ENSG00000095015	ENSG00000070423
Uniprot IDs		Q13233	A0A024R206 A8K0Q1 Q9BV68
PDB IDs			2N9O 2N9P
Enriched GO Terms of Interacting Partners?
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