MEIS2 and ANXA1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		MEIS2	ANXA1
Description		Meis homeobox 2	annexin A1
Image
GO Annotations	Cellular Component	Nuclear Chromatin Perinuclear Region Of Cytoplasm	Cornified Envelope Phagocytic Cup Extracellular Region Extracellular Space Nucleus Nucleoplasm Cytoplasm Endosome Cytosol Actin Filament Plasma Membrane Adherens Junction Focal Adhesion Cell Surface Basolateral Plasma Membrane Apical Plasma Membrane Lateral Plasma Membrane Extrinsic Component Of Membrane Cytoplasmic Vesicle Membrane Extrinsic Component Of External Side Of Plasma Membrane Extrinsic Component Of Endosome Membrane Motile Cilium Early Endosome Membrane Mitochondrial Membrane Vesicle Protein-containing Complex Sarcolemma Mast Cell Granule Collagen-containing Extracellular Matrix Extracellular Exosome Synaptic Membrane
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Transcription Coregulator Activity Transcription Corepressor Activity Protein Binding Transcription Factor Binding	Single-stranded DNA Binding Single-stranded RNA Binding Signaling Receptor Binding Calcium Ion Binding Protein Binding Phospholipid Binding Calcium-dependent Phospholipid Binding Phospholipase A2 Inhibitor Activity Double-stranded DNA-dependent ATP-dependent DNA Helicase Activity Identical Protein Binding Calcium-dependent Protein Binding Cadherin Binding Involved In Cell-cell Adhesion DNA/DNA Annealing Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Eye Development Transcription By RNA Polymerase II Visual Learning Response To Mechanical Stimulus Pancreas Development Negative Regulation Of Myeloid Cell Differentiation Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Transcription By RNA Polymerase II Response To Growth Factor Positive Regulation Of Cardiac Muscle Myoblast Proliferation	Neutrophil Homeostasis Adaptive Immune Response Monocyte Chemotaxis Regulation Of Leukocyte Migration Phagocytosis Inflammatory Response Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Regulation Of Cell Shape Response To X-ray Myoblast Migration Involved In Skeletal Muscle Regeneration Peptide Cross-linking Cytokine-mediated Signaling Pathway Insulin Secretion Keratinocyte Differentiation Prostate Gland Development Endocrine Pancreas Development Positive Regulation Of Vesicle Fusion Positive Regulation Of Prostaglandin Biosynthetic Process Actin Cytoskeleton Reorganization Response To Estradiol DNA Duplex Unwinding Regulation Of Interleukin-1 Production Positive Regulation Of Interleukin-2 Production Positive Regulation Of Neutrophil Apoptotic Process Cellular Response To Vascular Endothelial Growth Factor Stimulus Gliogenesis Positive Regulation Of T Cell Proliferation Regulation Of Cell Proliferation Response To Drug Negative Regulation Of Apoptotic Process Response To Peptide Hormone Estrous Cycle Innate Immune Response Positive Regulation Of T-helper 1 Cell Differentiation Negative Regulation Of T-helper 2 Cell Differentiation Negative Regulation Of Exocytosis Alpha-beta T Cell Differentiation Regulation Of Hormone Secretion Arachidonic Acid Secretion Regulation Of Inflammatory Response Cellular Response To Hydrogen Peroxide Hepatocyte Differentiation Prolactin Secretion Response To Interleukin-1 Cellular Response To Glucocorticoid Stimulus Granulocyte Chemotaxis Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Wound Healing Neutrophil Clearance Cell-cell Adhesion Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Phospholipase A2 Activity Negative Regulation Of Interleukin-8 Secretion
Pathways			G alpha (q) signalling events G alpha (i) signalling events Formyl peptide receptors bind formyl peptides and many other ligands Smooth Muscle Contraction Interleukin-4 and Interleukin-13 signaling
Drugs			Amcinonide Hydrocortisone Dexamethasone
Diseases
GWAS		Angiotensin-converting enzyme inhibitor intolerance ( 28030426) Hyperactive-impulsive symptoms ( 18821565) Intraocular pressure ( 24002674) Major depressive disorder ( 27479909) Post bronchodilator FEV1 in COPD ( 26634245) Response to antipsychotic treatment ( 20195266) Restless legs syndrome ( 29029846) Voxel-wise structural brain imaging measurements in Alzheimerâ€™s disease ( 30584014)	Blood protein levels ( 28240269) Chronotype ( 30696823) Metabolite levels ( 23823483) Parkinson's disease ( 26227905) Schizophrenia, bipolar disorder and depression (combined) ( 20713499) Urate levels in obese individuals ( 25811787)
Interacting Genes		14 interacting genes: ANXA1 APP ARNT2 C1orf94 CCDC196 DGCR6 HOXA13 HOXA9 OSGIN1 PBX1 RBPMS SQSTM1 TRIM25 ZNHIT3	33 interacting genes: APBB1 CCT7 COPS6 CSAD CZIB DYSF EGFR ERG28 FAF1 FPR1 GAPDH HMGA1 HSPB1 KLHL23 KMT2B KRT8 LRIF1 MEIS2 OTUB1 PRKCI RPA1 S100A11 SRC SUMO2 TGM2 TRPM7 UBE2D1 UBE2I UBE3A UCHL5 UNC119 USP7 YWHAQ
Entrez ID		4212	301
HPRD ID		03443	01060
Ensembl ID		ENSG00000134138	ENSG00000135046
Uniprot IDs		A0A024R9L4 B3KP81 B3KPD8 B7Z6F6 O14770	P04083 Q5TZZ9
PDB IDs		3K2A 4XRM 5BNG 5EG0	1AIN 1BO9 1QLS 5VFW
Enriched GO Terms of Interacting Partners?
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