MDK and SDC4

Number of citations of the paper that reports this interaction (PubMedID 8621465)
16

Data Source:
HPRD (in vitro)

		MDK	SDC4
Description		midkine	syndecan 4
Image
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Cell Projection Collagen-containing Extracellular Matrix	Golgi Lumen Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Cell Surface Costamere Lysosomal Lumen Membrane Raft Extracellular Exosome
	Molecular Function	Protein Binding Growth Factor Activity Heparin Binding Chondroitin Sulfate Binding Heparan Sulfate Binding	Fibronectin Binding Protein Kinase C Binding Protein Binding Identical Protein Binding Thrombospondin Receptor Activity
	Biological Process	Behavioral Fear Response Leukocyte Chemotaxis Involved In Inflammatory Response T Cell Activation Involved In Immune Response Positive Regulation Of Leukocyte Chemotaxis Cytoskeleton Organization Negative Regulation Of Cell Adhesion Signal Transduction Notch Signaling Pathway Nervous System Development Short-term Memory Response To Wounding Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Macrophage Chemotaxis Positive Regulation Of Keratinocyte Proliferation Positive Regulation Of Neuron Projection Development Response To Auditory Stimulus Dentate Gyrus Development Cerebellar Granular Layer Development Cerebral Cortex Development Cell Differentiation Negative Regulation Of Ossification Adrenal Gland Development Positive Regulation Of Cell Migration Defecation Regulation Of Chondrocyte Differentiation Tissue Regeneration Response To Drug Negative Regulation Of Neuron Apoptotic Process Estrous Cycle Positive Regulation Of T Cell Differentiation Negative Regulation Of Regulatory T Cell Differentiation Positive Regulation Of Cell Adhesion Positive Regulation Of Transcription, DNA-templated Regulation Of Bone Remodeling Oogenesis Positive Regulation Of Oligodendrocyte Differentiation Positive Regulation Of Inflammatory Response Regulation Of Behavior Response To Glucocorticoid Positive Regulation Of Cell Division Positive Regulation Of Cartilage Development Positive Regulation Of Smooth Muscle Cell Chemotaxis Positive Regulation Of Neutrophil Chemotaxis Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Inflammatory Response To Wounding Positive Regulation Of Inflammatory Response To Wounding Glial Cell Projection Elongation Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Leukocyte Cell-cell Adhesion Negative Regulation Of Epithelial Cell Apoptotic Process Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Positive Regulation Blood Vessel Branching Positive Regulation Of Vascular Endothelial Cell Proliferation Positive Regulation Of Artery Morphogenesis Positive Regulation Of Neural Precursor Cell Proliferation Regulation Of Actin Cytoskeleton Reorganization Positive Regulation Of Hepatocyte Proliferation Positive Regulation Of Neutrophil Extravasation Positive Regulation Of Interleukin-12 Secretion Positive Regulation Of Neuron Migration	Retinoid Metabolic Process Ureteric Bud Development Neural Tube Closure Glycosaminoglycan Biosynthetic Process Glycosaminoglycan Catabolic Process Regulation Of Fibroblast Migration Cell Migration Wound Healing Negative Regulation Of T Cell Proliferation Positive Regulation Of Protein Kinase Activity Leukocyte Migration Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Focal Adhesion Assembly Inner Ear Receptor Cell Stereocilium Organization Positive Regulation Of Exosomal Secretion Positive Regulation Of Extracellular Exosome Assembly
Pathways		NOTCH2 Activation and Transmission of Signal to the Nucleus	A tetrasaccharide linker sequence is required for GAG synthesis HS-GAG biosynthesis HS-GAG biosynthesis HS-GAG degradation Cell surface interactions at the vascular wall Syndecan interactions Syndecan interactions Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective EXT2 causes exostoses 2 Defective EXT1 causes exostoses 1, TRPS2 and CHDS Defective B3GALT6 causes EDSP2 and SEMDJL1 Retinoid metabolism and transport
Drugs
Diseases
GWAS		Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Autism spectrum disorder or schizophrenia ( 28540026) Feeling miserable ( 29500382) Immunoglobulin A ( 20694011) Schizophrenia ( 28991256 29483656 30285260)	Psoriasis ( 20953189)
Interacting Genes		20 interacting genes: ALK FBXO7 JAK1 JAK2 LRP1 LRP2 LRP6 LRP8 MAPK6 NCL PTPRZ1 RPL18A SDC1 SDC3 SDC4 SRPK2 STAT1 TGM1 TSPAN1 UBQLN4	15 interacting genes: CASK CCL5 CXCR4 GIPC1 MDK PRKCA PRKCD PTEN PXN SDCBP SGTA TANK TGFB1I1 TGFB3 UBC
Entrez ID		4192	6385
HPRD ID		01200	08366
Ensembl ID		ENSG00000110492	ENSG00000124145
Uniprot IDs		P21741	B4E1S6 P31431
PDB IDs		1MKC 1MKN	1EJP 1EJQ 1OBY 1YBO
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?