MDH1 and FUS

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		MDH1	FUS
Description		malate dehydrogenase 1	FUS RNA binding protein
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space Cytosol Extracellular Exosome	Nucleus Nucleoplasm Polysome Perikaryon Dendritic Spine Head Perinuclear Region Of Cytoplasm
	Molecular Function	Malic Enzyme Activity Protein Binding L-malate Dehydrogenase Activity Diiodophenylpyruvate Reductase Activity NAD Binding	DNA Binding Chromatin Binding Transcription Coregulator Activity Transcription Coactivator Activity RNA Binding MRNA 3'-UTR Binding Protein Binding Estrogen Receptor Binding Myosin V Binding Ionotropic Glutamate Receptor Binding Identical Protein Binding Metal Ion Binding Retinoid X Receptor Binding Thyroid Hormone Receptor Binding
	Biological Process	Gluconeogenesis Tricarboxylic Acid Cycle Oxaloacetate Metabolic Process Malate Metabolic Process NADH Metabolic Process NAD Metabolic Process	MRNA Splicing, Via Spliceosome Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II RNA Splicing Regulation Of RNA Splicing MRNA Stabilization Protein Homooligomerization Cellular Response To Calcium Ion Positive Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Double-strand Break Repair Via Homologous Recombination
Pathways		Gluconeogenesis	mRNA Splicing - Major Pathway
Drugs		NADH 2'-Monophosphoadenosine 5'-Diphosphoribose Artenimol
Diseases			Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease Myxoid liposarcoma
GWAS		Asthma and attention deficit hyperactivity disorder ( 31619474) Blood protein levels ( 30072576) Smoking status (ever vs never smokers) ( 30643258)	Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756)
Interacting Genes		10 interacting genes: EGFR FUS GPD1 HSD17B10 HSPB2 MPP3 SERPINB5 TERF1 TERF2IP TP53	45 interacting genes: AKT1 ARID1A ATXN1L CTNNB1 ESRRA EWSR1 GRIN1 GRIN2D IL7R ILF3 KHDRBS3 MAX MDH1 NKD2 NUPR1 POLR2A PRMT1 PSMB7 PTBP1 RBMX RELA RXRA SAFB2 SF1 SFPQ SMARCB1 SMARCC1 SMARCC2 SMARCD1 SPI1 SRRM1 SRSF10 SRSF2 SRSF4 SRSF9 SS18 SUV39H1 TARDBP TDRD3 THRA TNIP1 UBQLN2 WBP4 YBX1 ZMYM2
Entrez ID		4190	2521
HPRD ID		01100	00660
Ensembl ID		ENSG00000014641	ENSG00000089280
Uniprot IDs		P40925 V9HWF2	P35637 Q13344 Q6IBQ5
PDB IDs			2LA6 2LCW 4FDD 4FQ3 5W3N 5XRR 5XSG 5YVG 5YVH 5YVI 6BWZ 6BXV 6BZP 6G99 6GBM 6KJ1 6KJ2 6KJ3 6KJ4
Enriched GO Terms of Interacting Partners?
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