MCL1 and BTRC

Number of citations of the paper that reports this interaction (PubMedID 17387146)
170

Data Source:
BioGRID (enzymatic study)

		MCL1	BTRC
Description		MCL1 apoptosis regulator, BCL2 family member	beta-transducin repeat containing E3 ubiquitin protein ligase
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GO Annotations	Cellular Component	Cell Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Outer Membrane Cytosol Membrane Integral Component Of Membrane Bcl-2 Family Protein Complex	Nucleoplasm Cytosol SCF Ubiquitin Ligase Complex Small-subunit Processome Pwp2p-containing Subcomplex Of 90S Preribosome
	Molecular Function	Protein Binding Protein Transmembrane Transporter Activity Protein Homodimerization Activity Protein Heterodimerization Activity BH3 Domain Binding	Ubiquitin-protein Transferase Activity Protein Binding Beta-catenin Binding Ligase Activity SnoRNA Binding Protein Phosphorylated Amino Acid Binding Protein Dimerization Activity Ubiquitin Protein Ligase Activity
	Biological Process	Cell Fate Determination Multicellular Organism Development Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Autophagy Cytokine-mediated Signaling Pathway Cellular Homeostasis Response To Cytokine Negative Regulation Of Apoptotic Process Protein Transmembrane Transport Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Anoikis Regulation Of Response To DNA Damage Stimulus Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Intrinsic Apoptotic Signaling Pathway	G2/M Transition Of Mitotic Cell Cycle Protein Polyubiquitination Maturation Of SSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Stimulatory C-type Lectin Receptor Signaling Pathway Protein Dephosphorylation Ubiquitin-dependent Protein Catabolic Process Signal Transduction Viral Process Wnt Signaling Pathway Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Destabilization Mammary Gland Epithelial Cell Proliferation NIK/NF-kappaB Signaling Fc-epsilon Receptor Signaling Pathway Regulation Of Circadian Rhythm Positive Regulation Of Circadian Rhythm Regulation Of I-kappaB Kinase/NF-kappaB Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of DNA-binding Transcription Factor Activity Post-translational Protein Modification Positive Regulation Of Proteolysis Negative Regulation Of Smoothened Signaling Pathway Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Rhythmic Process T Cell Receptor Signaling Pathway Stress-activated MAPK Cascade Branching Involved In Mammary Gland Duct Morphogenesis Regulation Of Canonical Wnt Signaling Pathway Regulation Of Proteasomal Protein Catabolic Process Interleukin-1-mediated Signaling Pathway Cellular Response To Organic Cyclic Compound Regulation Of Mitotic Cell Cycle Phase Transition
Pathways		Interleukin-4 and Interleukin-13 signaling	Activation of NF-kappaB in B cells Prolactin receptor signaling SCF-beta-TrCP mediated degradation of Emi1 Vpu mediated degradation of CD4 Degradation of beta-catenin by the destruction complex Downstream TCR signaling Regulation of PLK1 Activity at G2/M Transition FCERI mediated NF-kB activation Deactivation of the beta-catenin transactivating complex Circadian Clock Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome NIK - noncanonical NF-kB signaling MAP3K8 (TPL2)-dependent MAPK1/3 activation Neddylation Interleukin-1 signaling Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Coronary artery disease ( 29212778) Eosinophil counts ( 27863252) FEV1 ( 30804560) Lung function (FEV1) ( 26635082) Lung function (FVC) ( 26635082 30804560) Melanoma ( 21983785) Monocyte count ( 29403010) Multiple sclerosis ( 31604244) Rhegmatogenous retinal detachment ( 23585552) Sum eosinophil basophil counts ( 27863252)	Diastolic blood pressure ( 30224653) Red blood cell count ( 29403010) Smoking status (ever vs never smokers) ( 30643258)
Interacting Genes		35 interacting genes: APEX1 BAD BAK1 BAX BBC3 BCL2L1 BCL2L11 BID BIK BMF BOK BTRC CASP3 DAD1 EP300 FBXW11 FBXW7 GSK3A GSK3B HIF1A HRK HUWE1 MAPK1 MAPK10 PCNA PIN1 PMAIP1 TNKS TPT1 TRAF6 UBXN6 UHRF2 USP13 USP9X VDAC1	78 interacting genes: AGO2 AMER1 ATF4 AXIN1 BORA CCND1 CCNE1 CDC25A CDC34 CDK1 CENPW CHPF CHUK CP CTNNB1 CUL1 DBN1 DEPTOR DLGAP5 E2F1 FBXW11 FBXW2 FOXO3 FZR1 GHR GLI2 GLI3 GSK3B HIPK2 HNRNPC HNRNPK HNRNPU ICE1 JUP KDR KMT5A LPCAT1 MCL1 MDM2 MYB MYC NFE2 NFKB1 NFKB2 NFKBIA NFKBIB PAQR3 PCDH8 PDCD4 PER2 PLK4 PRDX1 PSMA3 PSMD4 RASSF5 RCAN1 RELA RNF7 SKP1 SMAD3 SMAD4 SMURF1 SMURF2 SUFU TACC1 TAZ TIAM1 TP63 TRIB2 TRIM9 TSPAN15 UBC UBE2D2 UBE2R2 UBQLN2 WEE1 XRCC1 ZC3H12A
Entrez ID		4170	8945
HPRD ID		08870	04596
Ensembl ID		ENSG00000143384	ENSG00000166167
Uniprot IDs		A0A087WT64 C8YZ26 Q07820	A0A0S2Z4P6 B2R8L3 B7Z3H4 Q68DS0 Q9Y297
PDB IDs		2KBW 2MHS 2NL9 2NLA 2PQK 3D7V 3IO9 3KJ0 3KJ1 3KJ2 3KZ0 3MK8 3PK1 3TWU 3WIX 3WIY 4BPI 4BPJ 4HW2 4HW3 4HW4 4OQ5 4OQ6 4WGI 4WMR 4WMS 4WMT 4WMU 4WMV 4WMW 4WMX 4ZBF 4ZBI 5C3F 5C6H 5FC4 5FDO 5FDR 5IEZ 5IF4 5JSB 5KU9 5LOF 5MES 5MEV 5UUM 5VKC 5VX2 5W89 5W8F 6B4L 6B4U 6BW2 6BW8 6FS0 6FS1 6FS2 6MBD 6MBE 6NE5 6O6F 6O6G 6OQB 6OQC 6OQD 6OQN 6OVC 6P3P 6QB3 6QB4 6QB6 6QFC 6QFI 6QFM 6QFQ 6QGD 6QXJ 6QYK 6QYL 6QYN 6QYO 6QYP 6QZ5 6QZ6 6QZ7 6QZ8 6QZB	1P22 2P64 6M90 6M91 6M92 6M93 6M94
Enriched GO Terms of Interacting Partners?
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