MCL1 and VDAC1

Number of citations of the paper that reports this interaction (PubMedID 15637055)
76

Data Source:
HPRD (in vitro)

		MCL1	VDAC1
Description		MCL1 apoptosis regulator, BCL2 family member	voltage dependent anion channel 1
Image
GO Annotations	Cellular Component	Cell Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Outer Membrane Cytosol Membrane Integral Component Of Membrane Bcl-2 Family Protein Complex	Nucleus Mitochondrion Mitochondrial Outer Membrane Mitochondrial Permeability Transition Pore Complex Plasma Membrane Synaptic Vesicle Membrane Mitochondrial Nucleoid Membrane Raft Pore Complex Extracellular Exosome
	Molecular Function	Protein Binding Protein Transmembrane Transporter Activity Protein Homodimerization Activity Protein Heterodimerization Activity BH3 Domain Binding	Protein Binding Voltage-gated Anion Channel Activity Porin Activity Protein Kinase Binding Identical Protein Binding Ion Channel Binding Protein-containing Complex Binding
	Biological Process	Cell Fate Determination Multicellular Organism Development Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Autophagy Cytokine-mediated Signaling Pathway Cellular Homeostasis Response To Cytokine Negative Regulation Of Apoptotic Process Protein Transmembrane Transport Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Anoikis Regulation Of Response To DNA Damage Stimulus Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Intrinsic Apoptotic Signaling Pathway	Behavioral Fear Response Pyruvate Metabolic Process Anion Transport Mitochondrial Calcium Ion Transmembrane Transport Apoptotic Process Neuron-neuron Synaptic Transmission Learning Inorganic Anion Transport Viral Process Macroautophagy Epithelial Cell Differentiation Anion Transmembrane Transport Regulation Of Autophagy Of Mitochondrion Negative Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		Interleukin-4 and Interleukin-13 signaling	Mitochondrial protein import Pink/Parkin Mediated Mitophagy Ub-specific processing proteases Pyruvate metabolism Mitochondrial calcium ion transport
Drugs			Aluminium monostearate
Diseases
GWAS		Blood protein levels ( 30072576) Coronary artery disease ( 29212778) Eosinophil counts ( 27863252) FEV1 ( 30804560) Lung function (FEV1) ( 26635082) Lung function (FVC) ( 26635082 30804560) Melanoma ( 21983785) Monocyte count ( 29403010) Multiple sclerosis ( 31604244) Rhegmatogenous retinal detachment ( 23585552) Sum eosinophil basophil counts ( 27863252)	Alopecia areata ( 25608926) Metabolite levels ( 23823483) Systemic lupus erythematosus ( 28714469) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		35 interacting genes: APEX1 BAD BAK1 BAX BBC3 BCL2L1 BCL2L11 BID BIK BMF BOK BTRC CASP3 DAD1 EP300 FBXW11 FBXW7 GSK3A GSK3B HIF1A HRK HUWE1 MAPK1 MAPK10 PCNA PIN1 PMAIP1 TNKS TPT1 TRAF6 UBXN6 UHRF2 USP13 USP9X VDAC1	22 interacting genes: ADRB2 BAK1 BAX BCL2L1 BCL2L11 CKMT1A CKMT1B CSNK2B DYNLT1 DYNLT3 GSN HK1 KLHL40 MCL1 PPIF PRKCE PRKN RAF1 RNF31 SUMO4 TOMM20 TUBA4A
Entrez ID		4170	7416
HPRD ID		08870	05137
Ensembl ID		ENSG00000143384	ENSG00000213585
Uniprot IDs		A0A087WT64 C8YZ26 Q07820	A0A1L1UHR1 B3KTS5 P21796
PDB IDs		2KBW 2MHS 2NL9 2NLA 2PQK 3D7V 3IO9 3KJ0 3KJ1 3KJ2 3KZ0 3MK8 3PK1 3TWU 3WIX 3WIY 4BPI 4BPJ 4HW2 4HW3 4HW4 4OQ5 4OQ6 4WGI 4WMR 4WMS 4WMT 4WMU 4WMV 4WMW 4WMX 4ZBF 4ZBI 5C3F 5C6H 5FC4 5FDO 5FDR 5IEZ 5IF4 5JSB 5KU9 5LOF 5MES 5MEV 5UUM 5VKC 5VX2 5W89 5W8F 6B4L 6B4U 6BW2 6BW8 6FS0 6FS1 6FS2 6MBD 6MBE 6NE5 6O6F 6O6G 6OQB 6OQC 6OQD 6OQN 6OVC 6P3P 6QB3 6QB4 6QB6 6QFC 6QFI 6QFM 6QFQ 6QGD 6QXJ 6QYK 6QYL 6QYN 6QYO 6QYP 6QZ5 6QZ6 6QZ7 6QZ8 6QZB	2JK4 2K4T 5JDP 5XDN 5XDO 6G6U 6G73
Enriched GO Terms of Interacting Partners?
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