SMAD3 and ZC3H12A

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		SMAD3	ZC3H12A
Description		SMAD family member 3	zinc finger CCCH-type containing 12A
Image
GO Annotations	Cellular Component	Nuclear Chromatin Cell Nucleus Nuclear Inner Membrane Nucleoplasm Transcription Factor Complex Cytoplasm Cytosol Plasma Membrane Receptor Complex SMAD Protein Complex Heteromeric SMAD Protein Complex	P-body Nucleus Nucleoplasm Cytoplasm Rough Endoplasmic Reticulum Cytoskeleton Rough Endoplasmic Reticulum Membrane Protein-containing Complex Cytoplasmic Ribonucleoprotein Granule Extrinsic Component Of Endoplasmic Reticulum Membrane
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Proximal Promoter Sequence-specific DNA Binding RNA Polymerase II Activating Transcription Factor Binding Transcription Coactivator Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Transcription Coregulator Activity Transforming Growth Factor Beta Receptor Binding Protein Binding Collagen Binding Beta-catenin Binding Transcription Factor Binding Zinc Ion Binding DEAD/H-box RNA Helicase Binding Protein Kinase Binding Phosphatase Binding Transforming Growth Factor Beta Receptor, Pathway-specific Cytoplasmic Mediator Activity Chromatin DNA Binding Ubiquitin Protein Ligase Binding Mineralocorticoid Receptor Binding Glucocorticoid Receptor Binding Enhancer Binding Identical Protein Binding Protein Homodimerization Activity Ubiquitin Binding BHLH Transcription Factor Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding Co-SMAD Binding R-SMAD Binding Primary MiRNA Binding	DNA Binding Chromatin Binding RNA Binding MRNA Binding MRNA 3'-UTR Binding Endoribonuclease Activity Exoribonuclease Activity Ribonuclease Activity Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding MiRNA Binding RNA Stem-loop Binding MRNA 3'-UTR AU-rich Region Binding Ribosome Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Ureteric Bud Development Response To Hypoxia In Utero Embryonic Development Mesoderm Formation Somitogenesis Liver Development Heart Looping Osteoblast Development Immune System Development Regulation Of Transcription By RNA Polymerase II Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Immune Response Cell Cycle Arrest Transforming Growth Factor Beta Receptor Signaling Pathway SMAD Protein Complex Assembly Endoderm Development Embryonic Pattern Specification Positive Regulation Of Gene Expression Positive Regulation Of Alkaline Phosphatase Activity Positive Regulation Of Epithelial To Mesenchymal Transition Regulation Of Striated Muscle Tissue Development Protein Deubiquitination Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Signal Transduction Involved In Regulation Of Gene Expression Negative Regulation Of Cell Growth Adrenal Gland Development Positive Regulation Of Cell Migration Positive Regulation Of Bone Mineralization Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Thyroid Gland Development Primary MiRNA Processing Positive Regulation Of Chondrocyte Differentiation Positive Regulation Of Interleukin-1 Beta Production Regulation Of Transforming Growth Factor Beta2 Production Positive Regulation Of Transforming Growth Factor Beta3 Production Activin Receptor Signaling Pathway Negative Regulation Of Osteoblast Proliferation Nodal Signaling Pathway Wound Healing T Cell Activation Negative Regulation Of Protein Catabolic Process Positive Regulation Of Protein Import Into Nucleus Negative Regulation Of Apoptotic Process Cell-cell Junction Organization Positive Regulation Of Nitric Oxide Biosynthetic Process Negative Regulation Of Fat Cell Differentiation Negative Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Transcription By RNA Polymerase II Paraxial Mesoderm Morphogenesis Developmental Growth Embryonic Foregut Morphogenesis Embryonic Cranial Skeleton Morphogenesis Regulation Of Epithelial Cell Proliferation Negative Regulation Of Inflammatory Response Regulation Of Immune Response Protein Stabilization Positive Regulation Of Positive Chemotaxis Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of Binding Negative Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Focal Adhesion Assembly Pericardium Development Transdifferentiation SMAD Protein Signal Transduction Negative Regulation Of Wound Healing Negative Regulation Of Lung Blood Pressure Lens Fiber Cell Differentiation Cellular Response To Cytokine Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Canonical Wnt Signaling Pathway Extrinsic Apoptotic Signaling Pathway Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway Positive Regulation Of Extracellular Matrix Assembly Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II Negative Regulation Of Cardiac Muscle Hypertrophy In Response To Stress	Nuclear-transcribed MRNA Catabolic Process, Endonucleolytic Cleavage-dependent Decay Angiogenesis Negative Regulation Of Protein Phosphorylation Positive Regulation Of Defense Response To Virus By Host Immune Response-activating Signal Transduction Apoptotic Process Inflammatory Response Cellular Response To DNA Damage Stimulus Nervous System Development Regulation Of Gene Expression Positive Regulation Of Autophagy Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Muscle Cell Apoptotic Process Positive Regulation Of Lipid Storage Positive Regulation Of Cell Death Viral Process Protein Deubiquitination Cell Differentiation Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Cellular Response To Oxidative Stress Cellular Response To Glucose Starvation Positive Regulation Of Protein Import Into Nucleus Negative Regulation Of Macrophage Activation Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation By Host Of Viral Genome Replication Negative Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Interleukin-1 Beta Secretion T Cell Receptor Signaling Pathway Protein Complex Oligomerization Defense Response To Virus Negative Regulation Of Cardiac Muscle Contraction Positive Regulation Of MRNA Catabolic Process 3'-UTR-mediated MRNA Destabilization Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor RNA Phosphodiester Bond Hydrolysis RNA Phosphodiester Bond Hydrolysis, Endonucleolytic RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Cellular Response To Virus Negative Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Execution Phase Of Apoptosis Negative Regulation Of Interleukin-6 Secretion Positive Regulation Of P38MAPK Cascade Negative Regulation Of NIK/NF-kappaB Signaling Negative Regulation Of Interferon-gamma Secretion Positive Regulation Of Protein Deubiquitination Negative Regulation Of Production Of MiRNAs Involved In Gene Silencing By MiRNA Cellular Response To Sodium Arsenite Negative Regulation Of Tumor Necrosis Factor Secretion Cellular Response To Ionomycin Cellular Response To Chemokine Negative Regulation Of T-helper 17 Cell Differentiation Positive Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of MiRNA Catabolic Process
Pathways		Signaling by NODAL Signaling by NODAL Signaling by Activin Downregulation of TGF-beta receptor signaling TGF-beta receptor signaling activates SMADs Downregulation of SMAD2/3:SMAD4 transcriptional activity Downregulation of SMAD2/3:SMAD4 transcriptional activity SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription SMAD2/3 Phosphorylation Motif Mutants in Cancer SMAD4 MH2 Domain Mutants in Cancer SMAD2/3 MH2 Domain Mutants in Cancer TGFBR1 KD Mutants in Cancer Ub-specific processing proteases RUNX3 regulates CDKN1A transcription RUNX3 regulates BCL2L11 (BIM) transcription Interleukin-37 signaling NOTCH4 Intracellular Domain Regulates Transcription FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes FOXO-mediated transcription of cell cycle genes FOXO-mediated transcription of cell cycle genes
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406 29785011) Allergic rhinitis ( 30013184 31361310) Allergy ( 27182965) Asthma ( 31361310 30929738 20860503 27182965 31619474 29785011 29273806) Asthma (adult onset) ( 31036433 30929738) Asthma (childhood onset) ( 31036433 30929738) Asthma (moderate or severe) ( 30552067) Asthma and hay fever ( 24388013) Asthma onset (childhood vs adult) ( 30929738) Asthma or allergic disease (pleiotropy) ( 29785011) Bipolar disorder ( 31043756) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Central corneal thickness ( 31798171 29760442) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Colorectal cancer or advanced adenoma ( 30510241) Corneal astigmatism ( 30306274) Corneal structure ( 23291589) Coronary artery disease ( 29212778 26343387) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary heart disease ( 17634449) Crohn's disease ( 28067908 21102463) Dental caries (decayed and filled deciduous teeth) ( 31533690) Diverticular disease ( 30177863) Eosinophil counts ( 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252) Estimated glomerular filtration rate ( 31152163 31015462) Femoral neck bone mineral density ( 29499414) Heel bone mineral density ( 30598549 28869591) Height ( 28552196 31562340) Inflammatory bowel disease ( 28067908 23128233) Intraocular pressure ( 29617998 31798171 29235454) Intraocular pressure and central corneal thickness (multi-trait analysis) ( 31798171) Lumbar spine bone mineral density ( 29499414) Lung cancer (smoking interaction) ( 24658283) Lung function (FVC) ( 30061609) Medication use (adrenergics, inhalants) ( 31015401) Medication use (glucocorticoids) ( 31015401) Metabolite levels ( 23823483) Myocardial infarction ( 26343387) Offspring birth weight ( 31043758) Osteoarthritis (hip) ( 30374069) Osteoarthritis of the hip or knee ( 30664745) Pediatric autoimmune diseases ( 26301688) Pulse pressure ( 27841878) Pursuit maintenance gain ( 29064472) Restless legs syndrome ( 29029846) Self-reported allergy ( 23817569) Spontaneous dizygotic twinning ( 27132594) Sum eosinophil basophil counts ( 27863252) Thyroid cancer ( 28195142) Ulcerative colitis ( 28067908) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412)	Eyebrow thickness ( 26926045)
Interacting Genes		276 interacting genes: AATF ACTB AKT1 ANAPC10 ANK3 APMAP APOB APP AR ARHGEF6 ATF2 ATF3 AXIN1 AXIN2 BLZF1 BPTF BRCA1 BRCA2 BTRC CAMK2G CCDC33 CDC16 CDC25A CDC27 CDK2 CDK4 CDK8 CDK9 CEBPA CEBPB CEBPD CFDP1 CFH CFLAR CHRD CLASRP CORO1A CPSF7 CPTP CREBBP CRX CSH2 CSNK1D CSNK1G2 CTCF CTNNB1 CUL1 CXXC5 CYP11A1 DAB2 DACH1 DDX5 DEDD DNAJB4 DNMT3L DVL1 E2F4 E2F5 EBI3 EID2 EIF4B EIF4ENIF1 EP300 EPAS1 EPB41 ERBIN ESR1 ESR2 ETS1 FBLN1 FHL2 FHL3 FLI1 FLNA FOS FOXG1 FOXH1 FOXO1 FOXO3 FOXO4 GGA1 GIT2 GLI3 GMEB1 GSC GSK3B GTF2IRD1 HDAC1 HDAC4 HDAC5 HEY1 HEYL HGS HIF1A HIPK2 HIVEP1 HMGA2 HNF4A HNRNPK HOXC11 HP HSPA4 HYAL2 IL37 ISL1 ITCH JPH3 JUN JUNB JUND KANSL1 KAT2B KDM2A KMT2B KPNB1 KRT10 KRT2 LBP LCK LEF1 LEMD3 LMNA MAGI2 MAP3K7 MAPK1 MAPK14 MAPK8 MAPK9 MAX MBD1 MCM3AP MDM4 MECOM MED15 MEN1 MEOX2 MTF2 MYC MYD88 MYO5B MYOCD MYOD1 NCOA6 NEDD4 NEDD4L NEDD9 NFIA NFYC NOTCH1 NOTCH4 NR3C1 NR4A1 NUP153 NUP214 OTUB1 PAEP PAPPA PARD3 PARP4 PAX8 PCDH1 PCK2 PEX6 PHC2 PIAS2 PIAS3 PIAS4 PIK3CA PIN1 PLAG1 PLAGL1 PLG PML PPM1A PPP1R12C PPP2R1A PRDM4 PRKAR1B PRKAR2A PROX1 PRTN3 PSMD11 RAB38 RANBP9 RARG RASD2 RASL12 RBL1 RBPMS RBX1 RCVRN RELA RIOK2 RIT1 RNF111 RNF31 RPA1 RPLP0 RRAS2 RUNX2 RUNX3 S100A4 SAP130 SERTAD1 SETD2 SF3A1 SF3B2 SIN3A SKI SKIL SKOR2 SMAD1 SMAD2 SMAD4 SMAD7 SMAD9 SMURF1 SMURF2 SNRNP70 SNW1 SP1 SPTBN1 SQSTM1 SREBF2 SRY SS18L1 ST6GALNAC2 STRAP STUB1 SVEP1 TANK TDP2 TEKT4 TF TFE3 TGFBR1 TGFBR2 TGIF1 TGIF2 TGM2 TLE5 TLR4 TMED1 TOB1 TP53 TP73 TPM3 TRIM33 TSC2 TSC22D4 UBQLN4 UCHL5 USP7 VDR VIM VSIR WEE1 WWP1 WWP2 XPO6 XRCC6 YBX1 YY1 ZBTB16 ZBTB3 ZC3H12A ZCCHC14 ZDHHC4 ZEB1 ZEB2 ZFYVE9 ZMYM2 ZMYND11 ZNF329 ZNF8 ZNF83	15 interacting genes: AHSP AIMP2 BTRC CYFIP2 EP300 HIF1A IKBKG IRAK2 KPNA2 P4HA3 SHBG SMAD3 TANK UBC ZC3H12D
Entrez ID		4088	80149
HPRD ID		04380	08021
Ensembl ID		ENSG00000166949	ENSG00000163874
Uniprot IDs		A0A024R5Z3 P84022 Q9P0T0	Q5D1E8
PDB IDs		1MHD 1MJS 1MK2 1OZJ 1U7F 2LAJ 2LB2 5OD6 5ODG 5XOC	3V32 3V33 3V34
Enriched GO Terms of Interacting Partners?
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