ZC3H12A and P4HA3

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		ZC3H12A	P4HA3
Description		zinc finger CCCH-type containing 12A	prolyl 4-hydroxylase subunit alpha 3
Image			No pdb structure
GO Annotations	Cellular Component	P-body Nucleus Nucleoplasm Cytoplasm Rough Endoplasmic Reticulum Cytoskeleton Rough Endoplasmic Reticulum Membrane Protein-containing Complex Cytoplasmic Ribonucleoprotein Granule Extrinsic Component Of Endoplasmic Reticulum Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Lumen
	Molecular Function	DNA Binding Chromatin Binding RNA Binding MRNA Binding MRNA 3'-UTR Binding Endoribonuclease Activity Exoribonuclease Activity Ribonuclease Activity Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding MiRNA Binding RNA Stem-loop Binding MRNA 3'-UTR AU-rich Region Binding Ribosome Binding Metal Ion Binding	Procollagen-proline 4-dioxygenase Activity Iron Ion Binding Protein Binding Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen, Incorporation Of Two Atoms Of Oxygen L-ascorbic Acid Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Endonucleolytic Cleavage-dependent Decay Angiogenesis Negative Regulation Of Protein Phosphorylation Positive Regulation Of Defense Response To Virus By Host Immune Response-activating Signal Transduction Apoptotic Process Inflammatory Response Cellular Response To DNA Damage Stimulus Nervous System Development Regulation Of Gene Expression Positive Regulation Of Autophagy Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Muscle Cell Apoptotic Process Positive Regulation Of Lipid Storage Positive Regulation Of Cell Death Viral Process Protein Deubiquitination Cell Differentiation Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Cellular Response To Oxidative Stress Cellular Response To Glucose Starvation Positive Regulation Of Protein Import Into Nucleus Negative Regulation Of Macrophage Activation Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation By Host Of Viral Genome Replication Negative Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Interleukin-1 Beta Secretion T Cell Receptor Signaling Pathway Protein Complex Oligomerization Defense Response To Virus Negative Regulation Of Cardiac Muscle Contraction Positive Regulation Of MRNA Catabolic Process 3'-UTR-mediated MRNA Destabilization Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor RNA Phosphodiester Bond Hydrolysis RNA Phosphodiester Bond Hydrolysis, Endonucleolytic RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Cellular Response To Virus Negative Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Execution Phase Of Apoptosis Negative Regulation Of Interleukin-6 Secretion Positive Regulation Of P38MAPK Cascade Negative Regulation Of NIK/NF-kappaB Signaling Negative Regulation Of Interferon-gamma Secretion Positive Regulation Of Protein Deubiquitination Negative Regulation Of Production Of MiRNAs Involved In Gene Silencing By MiRNA Cellular Response To Sodium Arsenite Negative Regulation Of Tumor Necrosis Factor Secretion Cellular Response To Ionomycin Cellular Response To Chemokine Negative Regulation Of T-helper 17 Cell Differentiation Positive Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of MiRNA Catabolic Process	Peptidyl-proline Hydroxylation To 4-hydroxy-L-proline Oxidation-reduction Process
Pathways			Collagen biosynthesis and modifying enzymes
Drugs
Diseases
GWAS		Eyebrow thickness ( 26926045)	Hippocampal atrophy ( 25625606)
Interacting Genes		15 interacting genes: AHSP AIMP2 BTRC CYFIP2 EP300 HIF1A IKBKG IRAK2 KPNA2 P4HA3 SHBG SMAD3 TANK UBC ZC3H12D	11 interacting genes: DTNBP1 HGS MAGEA2B MAGEC2 MEOX2 NDN NUTM1 P4HB SERTAD1 WDR62 ZC3H12A
Entrez ID		80149	283208
HPRD ID		08021	16413
Ensembl ID		ENSG00000163874	ENSG00000149380
Uniprot IDs		Q5D1E8	Q7Z4N8
PDB IDs		3V32 3V33 3V34
Enriched GO Terms of Interacting Partners?
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