M6PR and GGA3

Number of citations of the paper that reports this interaction (PubMedID 11387475)
128

Data Source:
HPRD (two hybrid, in vitro)

		M6PR	GGA3
Description		mannose-6-phosphate receptor, cation dependent	golgi associated, gamma adaptin ear containing, ARF binding protein 3
Image
GO Annotations	Cellular Component	Lysosomal Membrane Endosome Late Endosome Trans-Golgi Network Plasma Membrane Integral Component Of Plasma Membrane Membrane Transport Vesicle Clathrin-coated Vesicle Membrane Trans-Golgi Network Membrane Perinuclear Region Of Cytoplasm	Golgi Apparatus Trans-Golgi Network Endosome Membrane Early Endosome Membrane Recycling Endosome Membrane
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding Protein Domain Specific Binding Retromer Complex Binding	Protein Binding ADP-ribosylation Factor Binding Ubiquitin Binding
	Biological Process	Protein Targeting To Lysosome Receptor-mediated Endocytosis Lysosomal Transport Endosome To Lysosome Transport Secretion Of Lysosomal Enzymes Membrane Organization	Intracellular Protein Transport Regulation Of Protein Stability Protein Destabilization Endocytic Recycling Protein Localization To Cell Surface Golgi To Plasma Membrane Protein Transport Cellular Protein Metabolic Process Positive Regulation Of Protein Catabolic Process Protein Localization To Lysosome Negative Regulation Of Amyloid-beta Formation
Pathways		Lysosome Vesicle Biogenesis Retrograde transport at the Trans-Golgi-Network Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis	TBC/RABGAPs MET receptor recycling Amyloid fiber formation
Drugs		Alglucosidase alfa 1-3 Sugar Ring of Pentamannosyl 6-Phosphate alpha-D-mannose 6-phosphate
Diseases
GWAS		SjÃ¶gren's syndrome ( 28076899) Total cholesterol levels ( 30275531)
Interacting Genes		6 interacting genes: GGA1 GGA2 GGA3 JUN PLIN3 REN	29 interacting genes: ADRA2A ADRA2B AFTPH AP1S2 ARAP3 ARF1 ARF3 CDKN2A CLINT1 CLTC CYTH2 EGFR GGA1 GGA2 IGF2R LRP10 M6PR PACS1 RABEP1 RNF11 RPS27A STAB1 SYNRG TBC1D3 TOLLIP TSG101 UBC VPS11 VPS18
Entrez ID		4074	23163
HPRD ID		01106	10443
Ensembl ID		ENSG00000003056	ENSG00000125447
Uniprot IDs		F5GX30 P20645	A8K6M0 B7Z456 Q9NZ52
PDB IDs		1JUQ	1JPL 1JUQ 1LF8 1P4U 1WR6 1YD8
Enriched GO Terms of Interacting Partners?
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