LYL1 and LMO1

Number of citations of the paper that reports this interaction (PubMedID 7957052)
66

Data Source:
BioGRID (two hybrid)
HPRD (in vivo)

		LYL1	LMO1
Description		LYL1 basic helix-loop-helix family member	LIM domain only 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus	Nucleus Nucleoplasm
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Protein Dimerization Activity	Protein Binding Metal Ion Binding
	Biological Process	Blood Vessel Maturation Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II B Cell Differentiation Positive Regulation Of Transcription, DNA-templated Definitive Hemopoiesis	Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II Regulation Of T Cell Homeostatic Proliferation Regulation Of Hematopoietic Stem Cell Differentiation
Pathways		NGF-stimulated transcription	RUNX1 regulates transcription of genes involved in differentiation of HSCs
Drugs
Diseases		Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia)
GWAS		Cognitive ability (MTAG) ( 29186694) Household income ( 31844048) Household income (MTAG) ( 31844048)	Alcohol consumption ( 23743675) Body mass index ( 31888951 26426971 28892062) Body mass index (age <50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Diastolic blood pressure ( 27618447) Fasting blood glucose ( 22581228) Fasting blood glucose (BMI interaction) ( 22581228) Height ( 31562340) Neuroblastoma ( 22941191 21124317) Offspring birth weight ( 31043758) Response to fenofibrate (HDL cholesterol levels) ( 27002377) Sporadic neuroblastoma ( 28545128) Systolic blood pressure ( 27618447)
Interacting Genes		9 interacting genes: BRD4 DRG1 LMO1 LMO2 NFKB1 NFKBIA RHOU TCF3 TCF4	39 interacting genes: ADAMTSL4 BCL11A BLZF1 CARD9 CBY2 CDCA7L CDX4 CEP170P1 CEP44 ERBIN GABPB1 GATA3 GOLGA2 IKZF3 KANK2 KRT40 LDB1 LPXN LYL1 LZTS2 NAGK NHLH1 NUTM1 PHC2 PTPN3 RBBP8 REL SAXO1 SNTA1 SOX5 TAL1 TAL2 TASOR2 TCF4 TFIP11 TLE5 TRIM27 ZBTB43 ZNF219
Entrez ID		4066	4004
HPRD ID		01046	01738
Ensembl ID		ENSG00000104903	ENSG00000166407
Uniprot IDs		P12980	E9PK83 P25800
PDB IDs
Enriched GO Terms of Interacting Partners?
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