LMO1 and LYL1

Number of citations of the paper that reports this interaction (PubMedID 7957052)
66

Data Source:
BioGRID (two hybrid)
HPRD (in vivo)

		LMO1	LYL1
Description		LIM domain only 1	LYL1 basic helix-loop-helix family member
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm	Nuclear Chromatin Nucleus
	Molecular Function	Protein Binding Metal Ion Binding	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Protein Dimerization Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II Regulation Of T Cell Homeostatic Proliferation Regulation Of Hematopoietic Stem Cell Differentiation	Blood Vessel Maturation Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II B Cell Differentiation Positive Regulation Of Transcription, DNA-templated Definitive Hemopoiesis
Pathways		RUNX1 regulates transcription of genes involved in differentiation of HSCs	NGF-stimulated transcription
Drugs
Diseases			Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia)
GWAS		Alcohol consumption ( 23743675) Body mass index ( 31888951 26426971 28892062) Body mass index (age <50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Diastolic blood pressure ( 27618447) Fasting blood glucose ( 22581228) Fasting blood glucose (BMI interaction) ( 22581228) Height ( 31562340) Neuroblastoma ( 22941191 21124317) Offspring birth weight ( 31043758) Response to fenofibrate (HDL cholesterol levels) ( 27002377) Sporadic neuroblastoma ( 28545128) Systolic blood pressure ( 27618447)	Cognitive ability (MTAG) ( 29186694) Household income ( 31844048) Household income (MTAG) ( 31844048)
Interacting Genes		39 interacting genes: ADAMTSL4 BCL11A BLZF1 CARD9 CBY2 CDCA7L CDX4 CEP170P1 CEP44 ERBIN GABPB1 GATA3 GOLGA2 IKZF3 KANK2 KRT40 LDB1 LPXN LYL1 LZTS2 NAGK NHLH1 NUTM1 PHC2 PTPN3 RBBP8 REL SAXO1 SNTA1 SOX5 TAL1 TAL2 TASOR2 TCF4 TFIP11 TLE5 TRIM27 ZBTB43 ZNF219	9 interacting genes: BRD4 DRG1 LMO1 LMO2 NFKB1 NFKBIA RHOU TCF3 TCF4
Entrez ID		4004	4066
HPRD ID		01738	01046
Ensembl ID		ENSG00000166407	ENSG00000104903
Uniprot IDs		E9PK83 P25800	P12980
PDB IDs
Enriched GO Terms of Interacting Partners?
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