LTC4S and MGST1

Number of citations of the paper that reports this interaction (PubMedID 11034337)
3

Data Source:
BioGRID (two hybrid)
HPRD (in vitro, in vivo)

		LTC4S	MGST1
Description		leukotriene C4 synthase	microsomal glutathione S-transferase 1
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Envelope Nuclear Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane Intracellular Membrane-bounded Organelle	Nucleus Mitochondrion Mitochondrial Outer Membrane Peroxisomal Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Membrane Azurophil Granule Membrane Apical Part Of Cell
	Molecular Function	Glutathione Transferase Activity Leukotriene-C4 Synthase Activity Glutathione Peroxidase Activity Protein Binding Enzyme Activator Activity Lipid Binding Identical Protein Binding	Glutathione Transferase Activity Glutathione Peroxidase Activity Protein Binding Identical Protein Binding Glutathione Binding Prostaglandin-E Synthase Activity
	Biological Process	Leukotriene Metabolic Process Leukotriene Biosynthetic Process Lipoxygenase Pathway Long-chain Fatty Acid Biosynthetic Process Positive Regulation Of Catalytic Activity Cellular Oxidant Detoxification Lipoxin Biosynthetic Process	Prostaglandin Biosynthetic Process Glutathione Metabolic Process Xenobiotic Metabolic Process Response To Organonitrogen Compound Response To Lipopolysaccharide Leydig Cell Differentiation Response To Drug Neutrophil Degranulation Oxidation-reduction Process Cellular Response To Lipid Hydroperoxide Cellular Oxidant Detoxification Glutathione Derivative Biosynthetic Process
Pathways		Synthesis of 5-eicosatetraenoic acids Synthesis of Leukotrienes (LT) and Eoxins (EX) Synthesis of Lipoxins (LX) Biosynthesis of maresin conjugates in tissue regeneration (MCTR) Biosynthesis of protectin and resolvin conjugates in tissue regeneration (PCTR and RCTR)	Glutathione conjugation Aflatoxin activation and detoxification Neutrophil degranulation
Drugs		Glutathione	Glutathione
Diseases
GWAS			Colorectal cancer (aspirin and/or NSAID use interaction) ( 25781442) Household income (MTAG) ( 31844048) Metabolite levels ( 23823483) Visceral fat ( 22589738)
Interacting Genes		3 interacting genes: ALOX5 ALOX5AP MGST1	2 interacting genes: LTC4S NELFB
Entrez ID		4056	4257
HPRD ID		02004	00705
Ensembl ID		ENSG00000213316	ENSG00000008394
Uniprot IDs		Q16873	A0A024RAX2 P10620
PDB IDs		2PNO 2UUH 2UUI 3B29 3HKK 3LEO 3PCV 4BPM 4J7T 4J7Y 4JC7 4JCZ 4JRZ 4WAB 5HV9 6R7D
Enriched GO Terms of Interacting Partners?
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