LTC4S and ALOX5AP

Number of citations of the paper that reports this interaction (PubMedID 19233132)
5

Data Source:
BioGRID (pull down)

		LTC4S	ALOX5AP
Description		leukotriene C4 synthase	arachidonate 5-lipoxygenase activating protein
Image
GO Annotations	Cellular Component	Nuclear Envelope Nuclear Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane Intracellular Membrane-bounded Organelle	Nuclear Envelope Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane Nuclear Membrane
	Molecular Function	Glutathione Transferase Activity Leukotriene-C4 Synthase Activity Glutathione Peroxidase Activity Protein Binding Enzyme Activator Activity Lipid Binding Identical Protein Binding	Glutathione Transferase Activity Leukotriene-C4 Synthase Activity Glutathione Peroxidase Activity Protein Binding Enzyme Activator Activity Protein N-terminus Binding Arachidonic Acid Binding
	Biological Process	Leukotriene Metabolic Process Leukotriene Biosynthetic Process Lipoxygenase Pathway Long-chain Fatty Acid Biosynthetic Process Positive Regulation Of Catalytic Activity Cellular Oxidant Detoxification Lipoxin Biosynthetic Process	Leukotriene Metabolic Process Leukotriene Biosynthetic Process Lipoxygenase Pathway Positive Regulation Of Catalytic Activity Protein Homotrimerization Cellular Response To Calcium Ion Cellular Oxidant Detoxification Lipoxin Biosynthetic Process
Pathways		Synthesis of 5-eicosatetraenoic acids Synthesis of Leukotrienes (LT) and Eoxins (EX) Synthesis of Lipoxins (LX) Biosynthesis of maresin conjugates in tissue regeneration (MCTR) Biosynthesis of protectin and resolvin conjugates in tissue regeneration (PCTR and RCTR)	Synthesis of 5-eicosatetraenoic acids Synthesis of Leukotrienes (LT) and Eoxins (EX) Synthesis of Lipoxins (LX)
Drugs		Glutathione	DG031 AM103
Diseases
GWAS			Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+epirubicin+/-5FU) ( 24025145) General risk tolerance (MTAG) ( 30643258) Non-word repetition ( 23738518)
Interacting Genes		3 interacting genes: ALOX5 ALOX5AP MGST1	4 interacting genes: ALOX5 CLIC1 GDF15 LTC4S
Entrez ID		4056	241
HPRD ID		02004	04742
Ensembl ID		ENSG00000213316	ENSG00000132965
Uniprot IDs		Q16873	A0A087WW23 P20292
PDB IDs		2PNO 2UUH 2UUI 3B29 3HKK 3LEO 3PCV 4BPM 4J7T 4J7Y 4JC7 4JCZ 4JRZ 4WAB 5HV9 6R7D	2Q7M 2Q7R
Enriched GO Terms of Interacting Partners?
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