LRP2 and LCN2

Number of citations of the paper that reports this interaction (PubMedID 15670845)
94

Data Source:
HPRD (in vitro)

		LRP2	LCN2
Description		LDL receptor related protein 2	lipocalin 2
Image
GO Annotations	Cellular Component	Lysosome Lysosomal Membrane Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Clathrin-coated Pit External Side Of Plasma Membrane Integral Component Of Membrane Apical Plasma Membrane Endocytic Vesicle Axon Dendrite Clathrin-coated Vesicle Membrane Brush Border Membrane Endosome Lumen Receptor Complex Extracellular Exosome	Extracellular Region Extracellular Space Cell Cytosol Specific Granule Lumen Extracellular Exosome
	Molecular Function	Calcium Ion Binding Protein Binding Drug Binding SH3 Domain Binding Insulin-like Growth Factor I Binding Chaperone Binding	Protease Binding Iron Ion Binding Small Molecule Binding Identical Protein Binding Enterobactin Binding
	Biological Process	Retinoid Metabolic Process Neural Tube Closure Secondary Heart Field Specification Outflow Tract Septum Morphogenesis Ventricular Compact Myocardium Morphogenesis Ventricular Septum Development Lipid Metabolic Process Endocytosis Receptor-mediated Endocytosis Sensory Perception Of Sound Cell Proliferation Male Gonad Development Protein Transport Metal Ion Transport Negative Regulation Of BMP Signaling Pathway Forebrain Development Aorta Development Vitamin D Metabolic Process Negative Regulation Of Apoptotic Process Response To Leptin Transcytosis Positive Regulation Of Neurogenesis Positive Regulation Of Protein Kinase B Signaling Vagina Development Coronary Artery Morphogenesis Membrane Organization Pulmonary Artery Morphogenesis Positive Regulation Of Oligodendrocyte Progenitor Proliferation Cellular Response To Growth Factor Stimulus Amyloid-beta Clearance Neuron Projection Arborization Folate Import Across Plasma Membrane Positive Regulation Of Lysosomal Protein Catabolic Process	Cellular Iron Ion Homeostasis Response To Virus Response To Herbicide Response To Mycotoxin Positive Regulation Of Gene Expression Siderophore Transport Cytokine-mediated Signaling Pathway Antimicrobial Humoral Response Positive Regulation Of Cell Projection Organization Cellular Response To Nutrient Levels Defense Response To Bacterium Neutrophil Degranulation Innate Immune Response Cellular Response To Hydrogen Peroxide Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Sequestering Of Iron Ion Positive Regulation Of Cold-induced Thermogenesis
Pathways		Vitamin D (calciferol) metabolism Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Retinoid metabolism and transport	Interleukin-4 and Interleukin-13 signaling Neutrophil degranulation Metal sequestration by antimicrobial proteins Iron uptake and transport Iron uptake and transport
Drugs		Urokinase Insulin Human Insulin Pork Gentamicin	Methyl Nonanoate (Ester) 2,3-Dihydroxy-Benzoic Acid Carboxymycobactin S 2,3,-Dihydroxybenzoylserine Carboxymycobactin T Trencam-3,2-Hopo
Diseases		Donnai-Barrow syndrome; Faciooculoacousticorenal syndrome
GWAS		Anorexia nervosa ( 21079607) Blood pressure (smoking interaction) ( 25189868) Chronic kidney disease ( 29124443) Creatinine levels ( 29124443 29403010) Estimated glomerular filtration rate ( 31152163 31015462 31451708 29779033 29124443 30604766) Estimated glomerular filtration rate in non-diabetics ( 31451708) Glomerular filtration rate ( 27588450 29403010) Glomerular filtration rate (creatinine) ( 28452372 26831199) Hyperuricemia ( 29124443) Macular thickness ( 30535121) Optic disc size ( 31809533) Proteinuria ( 30476138) Proteinuria (mild) ( 30476138) Proteinuria (moderate to severe) ( 30476138) Relapse in multiple sclerosis ( 28739605) Serum creatinine levels ( 29779033) Serum uric acid levels ( 30993211 29124443 29403010) Urate levels ( 31578528 20139978)
Interacting Genes		51 interacting genes: ALB ANAPC10 ANKRA2 ANKS1B APBA2 APBB1 APOB APOE APOH APP ATN1 CDC42 CLU CUBN DAB1 DAB2 DLG1 DLG2 DLG3 DLG4 GC GIPC1 GPRASP1 INS ITGB1BP1 LCN2 LDLRAP1 LPA LPL LRP2BP LRPAP1 MAGI1 MAPK8IP1 MAPK8IP2 MDK NOS1AP PIP5K1C PLAU RAC1 RBP1 RHOA SCGB1A1 SCN3A SERPINE1 SLC9A3 SNX17 SYNJ2BP TG THBS1 TLN1 TTR	4 interacting genes: HGF LRP2 MMP2 MMP9
Entrez ID		4036	3934
HPRD ID		02509	02551
Ensembl ID		ENSG00000081479	ENSG00000148346
Uniprot IDs		P98164 Q7Z5C0 Q7Z5C1	P80188
PDB IDs		2M0P	1DFV 1L6M 1NGL 1QQS 1X71 1X89 1X8U 3BY0 3CBC 3CMP 3DSZ 3DTQ 3FW4 3FW5 3HWD 3HWE 3HWF 3HWG 3I0A 3K3L 3PEC 3PED 3T1D 3TF6 3TZS 3U0D 4GH7 4IAW 4IAX 4K19 4MVI 4MVK 4MVL 4QAE 4ZFX 4ZHC 4ZHD 4ZHF 4ZHG 4ZHH 5JR8 5KHP 5KIC 5KID 5MHH 5N47 5N48 5NKN 6GQZ 6GR0 6O5D 6QMU
Enriched GO Terms of Interacting Partners?
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