LCN2 and MMP2

Number of citations of the paper that reports this interaction (PubMedID 7683678)
264

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		LCN2	MMP2
Description		lipocalin 2	matrix metallopeptidase 2
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cell Cytosol Specific Granule Lumen Extracellular Exosome	Extracellular Region Extracellular Space Nucleus Mitochondrion Plasma Membrane Sarcomere Collagen-containing Extracellular Matrix
	Molecular Function	Protease Binding Iron Ion Binding Small Molecule Binding Identical Protein Binding Enterobactin Binding	Endopeptidase Activity Metalloendopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Metallopeptidase Activity Zinc Ion Binding
	Biological Process	Cellular Iron Ion Homeostasis Response To Virus Response To Herbicide Response To Mycotoxin Positive Regulation Of Gene Expression Siderophore Transport Cytokine-mediated Signaling Pathway Antimicrobial Humoral Response Positive Regulation Of Cell Projection Organization Cellular Response To Nutrient Levels Defense Response To Bacterium Neutrophil Degranulation Innate Immune Response Cellular Response To Hydrogen Peroxide Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Sequestering Of Iron Ion Positive Regulation Of Cold-induced Thermogenesis	Angiogenesis Response To Hypoxia Blood Vessel Maturation Intramembranous Ossification Proteolysis Embryo Implantation Cytokine-mediated Signaling Pathway Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Catabolic Process Cellular Response To Reactive Oxygen Species Endodermal Cell Differentiation Cellular Protein Metabolic Process Ephrin Receptor Signaling Pathway Tissue Remodeling Face Morphogenesis Bone Trabecula Formation Cellular Response To Amino Acid Stimulus Response To Amyloid-beta Positive Regulation Of Vascular Smooth Muscle Cell Proliferation
Pathways		Interleukin-4 and Interleukin-13 signaling Neutrophil degranulation Metal sequestration by antimicrobial proteins Iron uptake and transport Iron uptake and transport	Collagen degradation Collagen degradation Degradation of the extracellular matrix Degradation of the extracellular matrix Activation of Matrix Metalloproteinases Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) EPH-ephrin mediated repulsion of cells Interleukin-4 and Interleukin-13 signaling Extra-nuclear estrogen signaling
Drugs		Methyl Nonanoate (Ester) 2,3-Dihydroxy-Benzoic Acid Carboxymycobactin S 2,3,-Dihydroxybenzoylserine Carboxymycobactin T Trencam-3,2-Hopo	Marimastat Captopril SC-74020 Halofuginone AE-941
Diseases			Choriocarcinoma Penile cancer Torg-Winchester syndrome
GWAS			Heel bone mineral density ( 30598549) Lack of premeditation ( 30718321)
Interacting Genes		4 interacting genes: HGF LRP2 MMP2 MMP9	37 interacting genes: A2M ACAN BACE1 BCAN CCL7 CLDN1 COL18A1 COL1A1 COL6A3 COL7A1 CXCL12 DCN EPHB2 FGFR1 HAPLN1 HSP90AA1 IGFBP3 IL1B ITGAV KISS1 LCN2 LGALS3 MMP14 MMP17 MMP25 MTDH MTNR1A MTNR1B PZP SPOCK1 TGFB1 THBS1 THBS2 TIMP1 TIMP2 TIMP3 TIMP4
Entrez ID		3934	4313
HPRD ID		02551	00386
Ensembl ID		ENSG00000148346	ENSG00000087245
Uniprot IDs		P80188	A0A024R6R4 P08253
PDB IDs		1DFV 1L6M 1NGL 1QQS 1X71 1X89 1X8U 3BY0 3CBC 3CMP 3DSZ 3DTQ 3FW4 3FW5 3HWD 3HWE 3HWF 3HWG 3I0A 3K3L 3PEC 3PED 3T1D 3TF6 3TZS 3U0D 4GH7 4IAW 4IAX 4K19 4MVI 4MVK 4MVL 4QAE 4ZFX 4ZHC 4ZHD 4ZHF 4ZHG 4ZHH 5JR8 5KHP 5KIC 5KID 5MHH 5N47 5N48 5NKN 6GQZ 6GR0 6O5D 6QMU	1CK7 1CXW 1EAK 1GEN 1GXD 1HOV 1J7M 1KS0 1QIB 1RTG 3AYU
Enriched GO Terms of Interacting Partners?
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