ARHGDIA and ST3GAL4

Number of citations of the paper that reports this interaction (PubMedID 16169070)
820

Data Source:
HPRD (two hybrid)

		ARHGDIA	ST3GAL4
Description		Rho GDP dissociation inhibitor alpha	ST3 beta-galactoside alpha-2,3-sialyltransferase 4
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Cytoskeleton Membrane Extracellular Exosome	Golgi Membrane Extracellular Region Membrane Integral Component Of Membrane Golgi Cisterna Membrane
	Molecular Function	Rho GDP-dissociation Inhibitor Activity GTPase Activator Activity Protein Binding Rac GTPase Binding	Beta-galactoside (CMP) Alpha-2,3-sialyltransferase Activity Sialyltransferase Activity Monosialoganglioside Sialyltransferase Activity
	Biological Process	Negative Regulation Of Cell Adhesion Rho Protein Signal Transduction Regulation Of Rho Protein Signal Transduction Negative Regulation Of Apoptotic Process Positive Regulation Of GTPase Activity Negative Regulation Of Axonogenesis Positive Regulation Of Axonogenesis Regulation Of Small GTPase Mediated Signal Transduction Semaphorin-plexin Signaling Pathway Regulation Of Actin Cytoskeleton Reorganization	Protein Glycosylation Glycoprotein Biosynthetic Process Glycolipid Biosynthetic Process Oligosaccharide Biosynthetic Process O-glycan Processing Keratan Sulfate Biosynthetic Process Lipid Glycosylation Cognition Sialylation Protein Sialylation
Pathways		Axonal growth inhibition (RHOA activation) Rho GTPase cycle Axonal growth stimulation	Pre-NOTCH Processing in Golgi Keratan sulfate biosynthesis Sialic acid metabolism Lewis blood group biosynthesis N-Glycan antennae elongation Termination of O-glycan biosynthesis
Drugs
Diseases
GWAS			Blood protein levels ( 29875488) C-reactive protein levels or LDL-cholesterol levels (pleiotropy) ( 27286809) C-reactive protein levels or total cholesterol levels (pleiotropy) ( 27286809) Cholesterol, total ( 24097068 25961943 20686565) Coronary artery disease ( 29212778) Factor VIII levels ( 30586737) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Height ( 31562340) LDL cholesterol ( 24097068 30275531 25961943 20686565) LDL cholesterol levels ( 28334899 30698716) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Liver enzyme levels (alkaline phosphatase) ( 22001757) Mean platelet volume ( 27863252) Medication use (HMG CoA reductase inhibitors) ( 31015401) Metabolite levels ( 23823483) Mumps ( 28928442) N-glycan levels ( 31163085) Platelet count ( 27863252) Platelet distribution width ( 27863252) Serum alkaline phosphatase levels ( 31666285 29403010) Soluble E-selectin levels ( 31217265) Total cholesterol levels ( 28334899 30275531) vWF levels ( 30586737)
Interacting Genes		41 interacting genes: ACTL6A ADRB2 ATXN3 BAK1 CASP3 CASP7 CBX5 CDC42 CDKN1B EP300 FEN1 HAAO HDAC6 HERPUD1 IKBKG JUP KAT2B MAPK6 NEDD4L POT1 RAC1 RAC2 RAC3 RDX RHOA RHOG RHOH SDHC SH3GL3 SIRT2 ST3GAL4 SUMO4 TERF1 TINF2 TRIM13 TWF2 UBE2I UBE2L6 UBE2R2 UFM1 VAV1	3 interacting genes: ARHGDIA CD8B GGCX
Entrez ID		396	6484
HPRD ID		03565	00084
Ensembl ID		ENSG00000141522	ENSG00000110080
Uniprot IDs		J3QQX2 P52565 V9HWE8	Q11206 Q6IBE6
PDB IDs		1CC0 1FSO 1FST 1FT0 1FT3 1HH4 1KMT 1QVY 1RHO 2BXW 2JHS 2JHT 2JHU 2JHV 2JHW 2JHX 2JHY 2JHZ 2JI0 2N80
Enriched GO Terms of Interacting Partners?
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