ARHGDIA and RAC3

Number of citations of the paper that reports this interaction (PubMedID 21900206)
114

Data Source:
BioGRID (two hybrid)

		ARHGDIA	RAC3
Description		Rho GDP dissociation inhibitor alpha	Rac family small GTPase 3
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GO Annotations	Cellular Component	Cytosol Cytoskeleton Membrane Extracellular Exosome	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Cell Cortex Endomembrane System Lamellipodium Growth Cone Cytoplasmic Vesicle Filamentous Actin Cell Projection Neuron Projection Neuronal Cell Body Intracellular Membrane-bounded Organelle Synapse Perinuclear Region Of Cytoplasm Extracellular Exosome Cell Periphery
	Molecular Function	Rho GDP-dissociation Inhibitor Activity GTPase Activator Activity Protein Binding Rac GTPase Binding	GTPase Activity Protein Binding GTP Binding Protein Kinase Binding Calcium-dependent Protein Binding
	Biological Process	Negative Regulation Of Cell Adhesion Rho Protein Signal Transduction Regulation Of Rho Protein Signal Transduction Negative Regulation Of Apoptotic Process Positive Regulation Of GTPase Activity Negative Regulation Of Axonogenesis Positive Regulation Of Axonogenesis Regulation Of Small GTPase Mediated Signal Transduction Semaphorin-plexin Signaling Pathway Regulation Of Actin Cytoskeleton Reorganization	Actin Filament Organization Establishment Or Maintenance Of Cell Polarity Rho Protein Signal Transduction Regulation Of Cell Shape Regulation Of Neuron Maturation Cerebral Cortex GABAergic Interneuron Development Cell Projection Assembly Actin Cytoskeleton Organization Cortical Cytoskeleton Organization Neuron Projection Development Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Cell Adhesion Mediated By Integrin Intracellular Signal Transduction Homeostasis Of Number Of Cells Within A Tissue Neuromuscular Process Controlling Balance Regulation Of Small GTPase Mediated Signal Transduction Synaptic Transmission, GABAergic Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Pathways		Axonal growth inhibition (RHOA activation) Rho GTPase cycle Axonal growth stimulation	Rho GTPase cycle PCP/CE pathway
Drugs
Diseases
GWAS
Interacting Genes		41 interacting genes: ACTL6A ADRB2 ATXN3 BAK1 CASP3 CASP7 CBX5 CDC42 CDKN1B EP300 FEN1 HAAO HDAC6 HERPUD1 IKBKG JUP KAT2B MAPK6 NEDD4L POT1 RAC1 RAC2 RAC3 RDX RHOA RHOG RHOH SDHC SH3GL3 SIRT2 ST3GAL4 SUMO4 TERF1 TINF2 TRIM13 TWF2 UBE2I UBE2L6 UBE2R2 UFM1 VAV1	9 interacting genes: ANKRD11 AR ARHGDIA ARHGDIB CIB1 ESR1 HNF1A NRBP1 PCNT
Entrez ID		396	5881
HPRD ID		03565	03629
Ensembl ID		ENSG00000141522	ENSG00000169750
Uniprot IDs		J3QQX2 P52565 V9HWE8	P60763
PDB IDs		1CC0 1FSO 1FST 1FT0 1FT3 1HH4 1KMT 1QVY 1RHO 2BXW 2JHS 2JHT 2JHU 2JHV 2JHW 2JHX 2JHY 2JHZ 2JI0 2N80	2C2H 2G0N 2IC5 2OV2 2QME
Enriched GO Terms of Interacting Partners?
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