CBX3 and H1-4

Number of citations of the paper that reports this interaction (PubMedID 16127177)
84

Data Source:
BioGRID (x-ray crystallography)
HPRD (in vitro)

		CBX3	H1-4
Description		chromobox 3	H1.4 linker histone, cluster member
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GO Annotations	Cellular Component	Chromosome, Centromeric Region Condensed Chromosome, Centromeric Region Nuclear Chromosome, Telomeric Region Chromatin Nucleus Nuclear Envelope Nuclear Inner Membrane Nucleoplasm Nuclear Euchromatin Nuclear Heterochromatin Spindle Nuclear Pericentric Heterochromatin Senescence-associated Heterochromatin Focus Site Of DNA Damage	Nuclear Nucleosome Nuclear Chromatin Nucleus Nuclear Euchromatin Nuclear Heterochromatin
	Molecular Function	Protein Binding Enzyme Binding Protein Domain Specific Binding Identical Protein Binding Histone Methyltransferase Binding	Double-stranded DNA Binding RNA Binding Calcium Ion Binding Protein Binding ATP Binding GTP Binding AMP Binding Chromatin DNA Binding Nucleosomal DNA Binding DATP Binding ADP Binding
	Biological Process	Chromatin Remodeling Cellular Response To DNA Damage Stimulus Negative Regulation Of Transcription, DNA-templated Rhythmic Process Negative Regulation Of G0 To G1 Transition Cellular Response To Dexamethasone Stimulus	Negative Regulation Of Transcription By RNA Polymerase II Nucleosome Assembly Regulation Of Transcription, DNA-templated Nucleosome Positioning Chromosome Condensation Negative Regulation Of Chromatin Silencing Negative Regulation Of DNA Recombination Histone H3-K4 Trimethylation Histone H3-K27 Trimethylation
Pathways		ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression RNA Polymerase I Promoter Escape Transcriptional Regulation by E2F6	Apoptosis induced DNA fragmentation Formation of Senescence-Associated Heterochromatin Foci (SAHF)
Drugs			Copper
Diseases
GWAS		Metabolite levels ( 23823483) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		32 interacting genes: ARL5A ATXN7L2 AURKA AURKB BARD1 CACNB4 CBX1 CBX5 DNMT3B DSN1 H1-4 H3-4 H3C1 H4C1 HECW2 HIPK2 KLF11 L3MBTL1 LBR MGA MIS12 MKI67 NSD3 NSL1 PIM1 SP100 TAF4 TRIM24 TRIM28 VHL ZNF10 ZNF496	6 interacting genes: CBX1 CBX3 CBX5 IL7R IRAK4 PRKCA
Entrez ID		11335	3008
HPRD ID		05130	07513
Ensembl ID		ENSG00000122565	ENSG00000168298
Uniprot IDs		A4D177 Q13185	A3R0T8 P10412
PDB IDs		2L11 3DM1 3KUP 3TZD 5T1I	3TZD 5JJZ 6H8P
Enriched GO Terms of Interacting Partners?
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