LAMP2 and UCHL1

Number of citations of the paper that reports this interaction (PubMedID 18550537)
75

Data Source:
HPRD (in vivo)

		LAMP2	UCHL1
Description		lysosomal associated membrane protein 2	ubiquitin C-terminal hydrolase L1
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GO Annotations	Cellular Component	Extracellular Space Cell Lysosome Lysosomal Membrane Late Endosome Plasma Membrane Membrane Phagocytic Vesicle Membrane Platelet Dense Granule Membrane Late Endosome Membrane Azurophil Granule Membrane Lysosomal Lumen Autolysosome Membrane Raft Extracellular Exosome Integral Component Of Autophagosome Membrane Membrane Microdomain Ficolin-1-rich Granule Membrane Lysosomal Matrix	Cytoplasm Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Neuronal Cell Body Neuron Projection Terminus Axon Cytoplasm
	Molecular Function	Protein Binding Enzyme Binding Protein Domain Specific Binding	Cysteine-type Endopeptidase Activity Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Omega Peptidase Activity Ligase Activity Ubiquitin Protein Ligase Binding Alpha-2A Adrenergic Receptor Binding Thiol-dependent Ubiquitinyl Hydrolase Activity Ubiquitin Binding
	Biological Process	Platelet Degranulation Protein Targeting Cellular Response To Starvation Protein Import Regulation Of Protein Stability Neutrophil Degranulation Muscle Cell Cellular Homeostasis Protein Stabilization Chaperone-mediated Autophagy Protein Targeting To Lysosome Involved In Chaperone-mediated Autophagy Establishment Of Protein Localization To Organelle Autophagosome Maturation Lysosomal Protein Catabolic Process	Response To Ischemia Axon Target Recognition Adult Walking Behavior Cell Proliferation Regulation Of Macroautophagy Protein Deubiquitination Sensory Perception Of Pain Axonal Transport Of Mitochondrion Cellular Response To Drug Eating Behavior Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of MAP Kinase Activity Muscle Fiber Development Neuromuscular Process
Pathways		Platelet degranulation Neutrophil degranulation Chaperone Mediated Autophagy	UCH proteinases
Drugs			Phenethyl Isothiocyanate
Diseases		Danon disease; X-linked vacuolar cardiomyopathy and myopathy	Parkinson's disease (PD)
GWAS			Cognitive performance ( 19734545) Metabolite levels ( 23823483)
Interacting Genes		4 interacting genes: AP4M1 CTSA PIAS4 UCHL1	28 interacting genes: ADRA2A ADRA2B ADRA2C ADRB2 AKT1 CBX1 CDKN1B COPS5 EGFR HSP90AA1 HSPA8 LAMP2 NCAM1 NEDD8 PLA2G2A PRKN RANBP9 SMN1 TERF2IP TINF2 TNFRSF1A TRIM54 TRIM63 UBC UBE2I USP15 USP21 USP28
Entrez ID		3920	7345
HPRD ID		02396	01877
Ensembl ID		ENSG00000005893	ENSG00000154277
Uniprot IDs		P13473	P09936 V9HW74
PDB IDs		2MOF 2MOM	2ETL 2LEN 3IFW 3IRT 3KVF 3KW5 4DM9 4JKJ
Enriched GO Terms of Interacting Partners?
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