LAMB3 and COL7A1

Number of citations of the paper that reports this interaction (PubMedID 9989793)
20

Data Source:
HPRD (in vivo, in vitro)

		LAMB3	COL7A1
Description		laminin subunit beta 3	collagen type VII alpha 1 chain
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Laminin-5 Complex Laminin Complex Collagen-containing Extracellular Matrix	Golgi Membrane Extracellular Region Collagen Type VII Trimer Basement Membrane Extracellular Space Endoplasmic Reticulum Lumen COPII-coated ER To Golgi Transport Vesicle Extracellular Matrix Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Collagen-containing Extracellular Matrix
	Molecular Function	Integrin Binding Structural Molecule Activity Extracellular Matrix Structural Constituent Protein Binding	Serine-type Endopeptidase Inhibitor Activity Protein Binding Extracellular Matrix Structural Constituent Conferring Tensile Strength
	Biological Process	Epidermis Development Animal Organ Morphogenesis Tissue Development Cell Migration Extracellular Matrix Organization Hemidesmosome Assembly Substrate Adhesion-dependent Cell Spreading Endodermal Cell Differentiation Brown Fat Cell Differentiation Basement Membrane Assembly	Growth Plate Cartilage Chondrocyte Morphogenesis ER To Golgi Vesicle-mediated Transport Cell Adhesion Epidermis Development Negative Regulation Of Endopeptidase Activity Extracellular Matrix Organization Endodermal Cell Differentiation COPII Vesicle Coating
Pathways		Degradation of the extracellular matrix Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures Anchoring fibril formation Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions Type I hemidesmosome assembly MET activates PTK2 signaling	Collagen degradation Collagen degradation Extracellular matrix organization Collagen biosynthesis and modifying enzymes Assembly of collagen fibrils and other multimeric structures COPII-mediated vesicle transport Integrin cell surface interactions Anchoring fibril formation Laminin interactions Laminin interactions Cargo concentration in the ER Collagen chain trimerization
Drugs
Diseases		Epidermolysis bullosa, junctional, including: Epidermolysis bullosa, junctional, Herlitz type (JEB-H); Epidermolysis bullosa, junctional, non-Herlitz type (JEB-nH); Epidermolysis bullosa, junctional, with pyloric atresia (JEB-PA)	Transient bullous dermolysis of the newborn Epidermolysis bullosa, dysprophic, including: ; Epidermolysis bullosa dystrophica, AD; Epidermolysis bullosa dystrophica, AR; Epidermolysis bullosa pruriginosa; Epidermolysis bullosa, pretibial
GWAS		Fentanyl consumption in laparoscopic-assisted colectomy (first 24 hours) ( 26566055)	Age at first sexual intercourse ( 27089180) Blood protein levels ( 29875488) Bone fracture in osteoporosis ( 28580392) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Ulcerative colitis ( 28067908)
Interacting Genes		6 interacting genes: BMP1 COL7A1 LAMA3 LAMC2 MDFI THBS1	15 interacting genes: BMP1 COL1A1 COL4A1 FBXL2 FN1 HSPA8 LAMA1 LAMA5 LAMB3 LAMC2 MIA3 MMP2 SHKBP1 THBS1 ZC3H7A
Entrez ID		3914	1294
HPRD ID		01032	00358
Ensembl ID		ENSG00000196878	ENSG00000114270
Uniprot IDs		A0A0S2Z3R6 Q13751	Q02388 Q59F16
PDB IDs
Enriched GO Terms of Interacting Partners?
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