KTN1 and IKBKE

Number of citations of the paper that reports this interaction (PubMedID 14743216)
300

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		KTN1	IKBKE
Description		kinectin 1	inhibitor of nuclear factor kappa B kinase subunit epsilon
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Integral Component Of Plasma Membrane Membrane Integral Component Of Membrane	Nucleus Nucleoplasm Cytoplasm Cytosol Endosome Membrane PML Body Mitochondrial Membrane
	Molecular Function	RNA Binding Protein Binding Kinesin Binding Cadherin Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity NF-kappaB-inducing Kinase Activity Protein Binding ATP Binding IkappaB Kinase Activity Protein Phosphatase Binding Ubiquitin Protein Ligase Binding K48-linked Polyubiquitin Modification-dependent Protein Binding Identical Protein Binding K63-linked Polyubiquitin Modification-dependent Protein Binding
	Biological Process	Microtubule-based Movement Post-translational Protein Modification Cellular Protein Metabolic Process	Protein Phosphorylation Immune Response I-kappaB Phosphorylation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of Lipid Storage Viral Process Peptidyl-serine Phosphorylation Negative Regulation Of Type I Interferon Production Response To Type I Interferon Response To Interferon-beta TRIF-dependent Toll-like Receptor Signaling Pathway NIK/NF-kappaB Signaling Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Type I Interferon-mediated Signaling Pathway Cellular Response To Virus
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) RHO GTPases activate KTN1 Post-translational protein phosphorylation	SUMOylation of immune response proteins TICAM1-dependent activation of IRF3/IRF7 TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation Negative regulators of DDX58/IFIH1 signaling Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
Drugs
Diseases
GWAS		Early spontaneous preterm birth ( 31194736) Lean body mass ( 28552196) Neurofibrillary tangles ( 31497858) Plasma anti-thyroglobulin levels ( 29678681) Subcortical brain region volumes ( 25607358)	Lymphocyte counts ( 27863252) Metabolite levels ( 23823483) Psoriasis ( 28537254) Systemic lupus erythematosus ( 27399966)
Interacting Genes		14 interacting genes: BNIP3 CDC42 CLEC7A EEF1D IKBKE KIF5B MEOX2 PLEKHA5 RAC1 RHOA RHOG SGTA SIRPA SYNE4	22 interacting genes: AZI2 BIRC2 BIRC3 CDC37 CHUK CYLD DDX3X FKBP5 HSP90AA1 HSP90AB1 IRF3 IRF5 KTN1 MBP NFKBIA RELA RIPK1 SIKE1 TANK TICAM1 TRIM27 XIAP
Entrez ID		3895	9641
HPRD ID		02661	05442
Ensembl ID		ENSG00000126777	ENSG00000263528
Uniprot IDs		A0A024R663 Q86UP2	A0A075B7B4 Q14164
PDB IDs
Enriched GO Terms of Interacting Partners?
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