IKBKE and SIKE1

Number of citations of the paper that reports this interaction (PubMedID 16281057)
56

Data Source:
HPRD (in vivo, two hybrid)

		IKBKE	SIKE1
Description		inhibitor of nuclear factor kappa B kinase subunit epsilon	suppressor of IKBKE 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Endosome Membrane PML Body Mitochondrial Membrane	Cytosol
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity NF-kappaB-inducing Kinase Activity Protein Binding ATP Binding IkappaB Kinase Activity Protein Phosphatase Binding Ubiquitin Protein Ligase Binding K48-linked Polyubiquitin Modification-dependent Protein Binding Identical Protein Binding K63-linked Polyubiquitin Modification-dependent Protein Binding	Protein Binding Rho GTPase Binding Protein Kinase Binding
	Biological Process	Protein Phosphorylation Immune Response I-kappaB Phosphorylation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of Lipid Storage Viral Process Peptidyl-serine Phosphorylation Negative Regulation Of Type I Interferon Production Response To Type I Interferon Response To Interferon-beta TRIF-dependent Toll-like Receptor Signaling Pathway NIK/NF-kappaB Signaling Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Type I Interferon-mediated Signaling Pathway Cellular Response To Virus
Pathways		SUMOylation of immune response proteins TICAM1-dependent activation of IRF3/IRF7 TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation Negative regulators of DDX58/IFIH1 signaling Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon	TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation
Drugs
Diseases
GWAS		Lymphocyte counts ( 27863252) Metabolite levels ( 23823483) Psoriasis ( 28537254) Systemic lupus erythematosus ( 27399966)
Interacting Genes		22 interacting genes: AZI2 BIRC2 BIRC3 CDC37 CHUK CYLD DDX3X FKBP5 HSP90AA1 HSP90AB1 IRF3 IRF5 KTN1 MBP NFKBIA RELA RIPK1 SIKE1 TANK TICAM1 TRIM27 XIAP	2 interacting genes: IKBKE TBK1
Entrez ID		9641	80143
HPRD ID		05442	07958
Ensembl ID		ENSG00000263528	ENSG00000052723
Uniprot IDs		A0A075B7B4 Q14164	Q9BRV8
PDB IDs			6AKK 6AKL 6AKM
Enriched GO Terms of Interacting Partners?
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