KRT14 and PKP1

Number of citations of the paper that reports this interaction (PubMedID 10852826)
24

Data Source:
HPRD (in vitro)

		KRT14	PKP1
Description		keratin 14	plakophilin 1
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Intermediate Filament Keratin Filament Basal Part Of Cell Extracellular Exosome Cell Periphery	Cornified Envelope Nucleus Nucleoplasm Cytoplasm Intermediate Filament Plasma Membrane Cell-cell Junction Adherens Junction Desmosome Ficolin-1-rich Granule Membrane Messenger Ribonucleoprotein Complex
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding Keratin Filament Binding	Protein Binding Lamin Binding Intermediate Filament Binding Structural Constituent Of Epidermis Cadherin Binding
	Biological Process	Aging Epidermis Development Response To Zinc Ion Response To Ionizing Radiation Keratinization Hemidesmosome Assembly Hair Cycle Intermediate Filament Bundle Assembly Cornification	Cell-cell Junction Assembly Cell Adhesion Signal Transduction Positive Regulation Of Gene Expression Keratinization Neutrophil Degranulation Intermediate Filament Bundle Assembly Cornification Cell-cell Adhesion Negative Regulation Of MRNA Catabolic Process
Pathways		Type I hemidesmosome assembly Keratinization Formation of the cornified envelope	Apoptotic cleavage of cell adhesion proteins Neutrophil degranulation Keratinization Formation of the cornified envelope
Drugs		Zinc
Diseases		Naegeli-Franceschetti-Jadassohn syndrome Dermatopathia pigmentosa reticularis Epidermolysis bullosa simplex, including: Epidermolysis bullosa simplex, Dowling-Meara type (EBS-DM); Epidermolysis bullosa simplex, Koebner type (EBS-K); Epidermolysis bullosa simplex, Weber-Cockayne type (EBS-WC); Epidermolysis bullosa simplex with mottled pigmentation (EBS-MP); Epidermolysis bullosa simplex with migratory circinate erythema; Epidermolysis bullosa simplex, recessive; Epidermolysis bullosa, lethal acantholytic	Ectodermal dysplasia/skin fragility syndrome
GWAS			Panic disorder ( 19165232)
Interacting Genes		7 interacting genes: APC DST HSPA5 KRT5 PKP1 TCHP TRADD	9 interacting genes: DSC1 DSG1 DSP GTF2IRD1 KRT14 KRT8 TNS2 UCHL5 VIM
Entrez ID		3861	5317
HPRD ID		01017	03579
Ensembl ID		ENSG00000186847	ENSG00000081277
Uniprot IDs		P02533	A0A024R952 Q13835
PDB IDs		3TNU	1XM9
Enriched GO Terms of Interacting Partners?
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