KISS1 and MMP24

Number of citations of the paper that reports this interaction (PubMedID 12879005)
29

Data Source:
HPRD (in vitro, in vivo)

		KISS1	MMP24
Description		KiSS-1 metastasis suppressor	matrix metallopeptidase 24
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cell Cytoplasm Apical Plasma Membrane Neuron Projection Neuronal Cell Body	Extracellular Space Integral Component Of Plasma Membrane Extracellular Matrix Trans-Golgi Network Membrane Extracellular Exosome
	Molecular Function	Protein Binding Kisspeptin Receptor Binding	Metalloendopeptidase Activity Enzyme Activator Activity Zinc Ion Binding Cadherin Binding
	Biological Process	Cytoskeleton Organization G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Negative Regulation Of Cell Proliferation Positive Regulation Of Luteinizing Hormone Secretion Positive Regulation Of MAPK Cascade Positive Regulation Of Synaptic Transmission Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G Protein-coupled Signaling Pathway Generation Of Ovulation Cycle Rhythm Positive Regulation Of Growth Hormone Secretion	Proteolysis Glial Cell Differentiation Extracellular Matrix Organization Collagen Catabolic Process Positive Regulation Of Catalytic Activity Cell-cell Adhesion Mediated By Cadherin Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Neuronal Stem Cell Population Maintenance Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules
Pathways		Peptide ligand-binding receptors G alpha (q) signalling events	Activation of Matrix Metalloproteinases
Drugs			Marimastat
Diseases
GWAS		Psychosis proneness (hypomanic personality scale and perceptual aberration scale) ( 28525603) Psychosis proneness (hypomanic personality scale and revised physical anhedonia scale) ( 28525603) Psychosis proneness (hypomanic personality scale and revised social anhedonia scale) ( 28525603) Psychosis proneness (hypomanic personality scale) ( 28525603) Response to cognitive-behavioural therapy in anxiety disorder ( 31123309)	Attention deficit hyperactivity disorder ( 18839057) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) HDL cholesterol levels ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Height ( 18391951) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		8 interacting genes: APP CREBBP KISS1R MMP14 MMP16 MMP2 MMP24 MMP9	1 interacting genes: KISS1
Entrez ID		3814	10893
HPRD ID		04475	05338
Ensembl ID		ENSG00000170498	ENSG00000125966
Uniprot IDs		Q15726	Q86VV6 Q9Y5R2
PDB IDs
Enriched GO Terms of Interacting Partners?
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