MMP24 and KISS1

Number of citations of the paper that reports this interaction (PubMedID 12879005)
29

Data Source:
HPRD (in vitro, in vivo)

		MMP24	KISS1
Description		matrix metallopeptidase 24	KiSS-1 metastasis suppressor
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Space Integral Component Of Plasma Membrane Extracellular Matrix Trans-Golgi Network Membrane Extracellular Exosome	Extracellular Region Extracellular Space Cell Cytoplasm Apical Plasma Membrane Neuron Projection Neuronal Cell Body
	Molecular Function	Metalloendopeptidase Activity Enzyme Activator Activity Zinc Ion Binding Cadherin Binding	Protein Binding Kisspeptin Receptor Binding
	Biological Process	Proteolysis Glial Cell Differentiation Extracellular Matrix Organization Collagen Catabolic Process Positive Regulation Of Catalytic Activity Cell-cell Adhesion Mediated By Cadherin Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Neuronal Stem Cell Population Maintenance Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules	Cytoskeleton Organization G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Negative Regulation Of Cell Proliferation Positive Regulation Of Luteinizing Hormone Secretion Positive Regulation Of MAPK Cascade Positive Regulation Of Synaptic Transmission Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G Protein-coupled Signaling Pathway Generation Of Ovulation Cycle Rhythm Positive Regulation Of Growth Hormone Secretion
Pathways		Activation of Matrix Metalloproteinases	Peptide ligand-binding receptors G alpha (q) signalling events
Drugs		Marimastat
Diseases
GWAS		Attention deficit hyperactivity disorder ( 18839057) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) HDL cholesterol levels ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Height ( 18391951) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Psychosis proneness (hypomanic personality scale and perceptual aberration scale) ( 28525603) Psychosis proneness (hypomanic personality scale and revised physical anhedonia scale) ( 28525603) Psychosis proneness (hypomanic personality scale and revised social anhedonia scale) ( 28525603) Psychosis proneness (hypomanic personality scale) ( 28525603) Response to cognitive-behavioural therapy in anxiety disorder ( 31123309)
Interacting Genes		1 interacting genes: KISS1	8 interacting genes: APP CREBBP KISS1R MMP14 MMP16 MMP2 MMP24 MMP9
Entrez ID		10893	3814
HPRD ID		05338	04475
Ensembl ID		ENSG00000125966	ENSG00000170498
Uniprot IDs		Q86VV6 Q9Y5R2	Q15726
PDB IDs
Enriched GO Terms of Interacting Partners?
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