KCNB1 and PTPRE

Number of citations of the paper that reports this interaction (PubMedID 12615930)
28

Data Source:
HPRD (in vitro)

		KCNB1	PTPRE
Description		potassium voltage-gated channel subfamily B member 1	protein tyrosine phosphatase receptor type E
Image		No pdb structure
GO Annotations	Cellular Component	Cell Plasma Membrane Voltage-gated Potassium Channel Complex Integral Component Of Membrane Lateral Plasma Membrane Cell Junction Axon Dendrite Dendrite Membrane Neuronal Cell Body Membrane Sarcolemma Perikaryon Postsynaptic Membrane	Nucleus Cytoplasm Plasma Membrane Integral Component Of Membrane
	Molecular Function	Voltage-gated Potassium Channel Activity Delayed Rectifier Potassium Channel Activity Protein Binding Ion Channel Binding Protein Heterodimerization Activity	Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Protein Binding
	Biological Process	Action Potential Vesicle Docking Involved In Exocytosis Glutamate Receptor Signaling Pathway Positive Regulation Of Norepinephrine Secretion Cellular Response To Nutrient Levels Positive Regulation Of Catecholamine Secretion Regulation Of Ion Transmembrane Transport Glucose Homeostasis Positive Regulation Of Calcium Ion-dependent Exocytosis Negative Regulation Of Insulin Secretion Regulation Of Insulin Secretion Protein Homooligomerization Cellular Response To Glucose Stimulus Potassium Ion Transmembrane Transport Protein Localization To Plasma Membrane Positive Regulation Of Protein Targeting To Membrane Regulation Of Action Potential Positive Regulation Of Long-term Synaptic Depression Regulation Of Motor Neuron Apoptotic Process	Protein Dephosphorylation Peptidyl-tyrosine Dephosphorylation Negative Regulation Of Insulin Receptor Signaling Pathway
Pathways		Voltage gated Potassium channels Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
Drugs		Dalfampridine	Alendronic acid
Diseases
GWAS		Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Diastolic blood pressure ( 30224653) Height ( 28552196) Obesity-related traits ( 23251661) Schizophrenia ( 25056061 29483656) White matter hyperintensity burden ( 25663218)	Response to amphetamines ( 22952603) Select biomarker traits ( 17903293) Triglyceride levels x loop diuretics use interaction ( 31806883)
Interacting Genes		18 interacting genes: CALM1 KCNB2 KCNE5 KCNG1 KCNG2 KCNG3 KCNG4 KCNH1 KCNS3 KCNV1 KCNV2 NEDD4L PTPRE SNAP25 SRC STX1A VAPA VAPB	10 interacting genes: FYN GRB2 KCNA5 KCNB1 MAPK1 MAPK3 PTPRD PTPRS SRC YES1
Entrez ID		3745	5791
HPRD ID		08983	02956
Ensembl ID		ENSG00000158445	ENSG00000132334
Uniprot IDs		Q14721	A8K2Z9 P23469 Q96P81
PDB IDs			2JJD 6D3F 6D4D 6D4F
Enriched GO Terms of Interacting Partners?
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