KCNB1 and KCNS3

Number of citations of the paper that reports this interaction (PubMedID 9362476)
74

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		KCNB1	KCNS3
Description		potassium voltage-gated channel subfamily B member 1	potassium voltage-gated channel modifier subfamily S member 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cell Plasma Membrane Voltage-gated Potassium Channel Complex Integral Component Of Membrane Lateral Plasma Membrane Cell Junction Axon Dendrite Dendrite Membrane Neuronal Cell Body Membrane Sarcolemma Perikaryon Postsynaptic Membrane	Golgi Apparatus Cytosol Plasma Membrane Voltage-gated Potassium Channel Complex Integral Component Of Membrane
	Molecular Function	Voltage-gated Potassium Channel Activity Delayed Rectifier Potassium Channel Activity Protein Binding Ion Channel Binding Protein Heterodimerization Activity	Voltage-gated Potassium Channel Activity Delayed Rectifier Potassium Channel Activity Potassium Channel Regulator Activity
	Biological Process	Action Potential Vesicle Docking Involved In Exocytosis Glutamate Receptor Signaling Pathway Positive Regulation Of Norepinephrine Secretion Cellular Response To Nutrient Levels Positive Regulation Of Catecholamine Secretion Regulation Of Ion Transmembrane Transport Glucose Homeostasis Positive Regulation Of Calcium Ion-dependent Exocytosis Negative Regulation Of Insulin Secretion Regulation Of Insulin Secretion Protein Homooligomerization Cellular Response To Glucose Stimulus Potassium Ion Transmembrane Transport Protein Localization To Plasma Membrane Positive Regulation Of Protein Targeting To Membrane Regulation Of Action Potential Positive Regulation Of Long-term Synaptic Depression Regulation Of Motor Neuron Apoptotic Process	Potassium Ion Transport Regulation Of Ion Transmembrane Transport Regulation Of Insulin Secretion Protein Homooligomerization Potassium Ion Transmembrane Transport
Pathways		Voltage gated Potassium channels Glucagon-like Peptide-1 (GLP1) regulates insulin secretion	Voltage gated Potassium channels Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
Drugs		Dalfampridine
Diseases
GWAS		Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Diastolic blood pressure ( 30224653) Height ( 28552196) Obesity-related traits ( 23251661) Schizophrenia ( 25056061 29483656) White matter hyperintensity burden ( 25663218)	Body fat percentage ( 31752434) Colonoscopy-negative controls vs population controls ( 29228715) Colorectal cancer ( 29228715) FEV1 ( 30804560) Height ( 28552196 31562340) Hip circumference adjusted for BMI ( 28552196) Lung function (FEV1) ( 28166213 26635082) Lung function (FEV1/FVC) ( 28166213 26635082 30804560) Lung function (FVC) ( 30804560) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Peak expiratory flow ( 30804560) QT interval (sulfonylurea treatment interaction) ( 27958378) Systolic blood pressure night-to-day ratio in hypertension ( 29973135) Urate levels in obese individuals ( 25811787)
Interacting Genes		18 interacting genes: CALM1 KCNB2 KCNE5 KCNG1 KCNG2 KCNG3 KCNG4 KCNH1 KCNS3 KCNV1 KCNV2 NEDD4L PTPRE SNAP25 SRC STX1A VAPA VAPB	1 interacting genes: KCNB1
Entrez ID		3745	3790
HPRD ID		08983	04865
Ensembl ID		ENSG00000158445	ENSG00000170745
Uniprot IDs		Q14721	Q9BQ31
PDB IDs
Enriched GO Terms of Interacting Partners?
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