JARID2 and NKX2-5

Number of citations of the paper that reports this interaction (PubMedID 15542826)
29

Data Source:
HPRD (in vivo, in vitro)

		JARID2	NKX2-5
Description		jumonji and AT-rich interaction domain containing 2	NK2 homeobox 5
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Mitochondrion Histone Methyltransferase Complex ESC/E(Z) Complex	Nuclear Chromatin Nucleus Transcription Factor Complex Cytoplasm Protein-containing Complex Protein-DNA Complex RNA Polymerase II Transcription Factor Complex
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Chromatin Binding Transcription Factor Binding Histone Demethylase Activity Histone Demethylase Activity (H3-trimethyl-K4 Specific)	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Transcription Factor Binding Protein Homodimerization Activity Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Liver Development Chromatin Remodeling Central Nervous System Development Negative Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Histone Methylation Histone H3-K4 Demethylation, Trimethyl-H3-K4-specific Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Transcription, DNA-templated Spleen Development Thymus Development Stem Cell Differentiation Positive Regulation Of Histone H3-K9 Methylation Negative Regulation Of Cardiac Muscle Cell Proliferation Cellular Response To Leukemia Inhibitory Factor	Negative Regulation Of Transcription By RNA Polymerase II Vasculogenesis Heart Looping Heart Morphogenesis Outflow Tract Septum Morphogenesis Cardiac Conduction System Development Bundle Of His Development Purkinje Myocyte Differentiation Cardiac Ventricle Formation Right Ventricular Cardiac Muscle Tissue Morphogenesis Ventricular Trabecula Myocardium Morphogenesis Apoptotic Process Involved In Heart Morphogenesis Septum Secundum Development Proepicardium Development Pulmonary Myocardium Development Adult Heart Development Positive Regulation Of Cell Proliferation Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Positive Regulation Of Transcription Via Serum Response Element Binding Positive Regulation Of Sodium Ion Transport Negative Regulation Of Myotube Differentiation Hemopoiesis Cell Differentiation Thyroid Gland Development Embryonic Heart Tube Development Negative Regulation Of Apoptotic Process Sarcomere Organization Positive Regulation Of Neuron Differentiation Positive Regulation Of Heart Contraction Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Spleen Development Positive Regulation Of Cardioblast Differentiation Ventricular Cardiac Myofibril Assembly Cardiac Muscle Cell Differentiation Cardiac Muscle Tissue Morphogenesis Atrial Cardiac Muscle Cell Development Ventricular Cardiac Muscle Cell Development Regulation Of Cardiac Muscle Contraction Pharyngeal System Development Cardiac Muscle Cell Proliferation Regulation Of Cardiac Muscle Cell Proliferation Cardiac Muscle Contraction Positive Regulation Of Transcription Initiation From RNA Polymerase II Promoter Heart Trabecula Formation Ventricular Septum Morphogenesis Atrial Septum Morphogenesis Atrioventricular Node Cell Development Atrioventricular Node Cell Fate Commitment Embryonic Heart Tube Left/right Pattern Formation Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Cardiac Conduction
Pathways		PRC2 methylates histones and DNA	YAP1- and WWTR1 (TAZ)-stimulated gene expression Physiological factors
Drugs
Diseases			Atrial septal defect Tetralogy of Fallot Congenital nongoitrous hypothyroidism (CHNG)
GWAS		Birth weight ( 31043758) Chronotype ( 30696823) Hand grip strength ( 29691431) Lymphoma ( 23349640) Multiple myeloma ( 27363682) Multiple sclerosis (severity) ( 19010793) Ovarian reserve ( 22116950)	Atrial fibrillation ( 30061737 29892015) Heart rate ( 23583979) Infantile hypertrophic pyloric stenosis ( 22306654) Ischemic stroke (cardioembolic) ( 29531354) PR interval ( 30046033 20062060) Resting heart rate ( 27798624) Stroke ( 26089329)
Interacting Genes		3 interacting genes: GATA4 NKX2-5 SETDB1	14 interacting genes: CAMTA2 CSNK2A1 FBXO25 FOXH1 GATA4 HDAC1 HIPK1 HIPK2 JARID2 KDM6A SRF TBX2 TBX5 TLE1
Entrez ID		3720	1482
HPRD ID		03355	02787
Ensembl ID		ENSG00000008083	ENSG00000183072
Uniprot IDs		Q92833	A0A0S2Z383 A0A0S2Z3K2 E5RH49 P52952
PDB IDs		5HYN 5LS6 6C23 6C24	3RKQ 4S0H
Enriched GO Terms of Interacting Partners?
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